孙伟光,博士,生物药学系。主要从事植物与真菌来源天然产物的活行评价及作用机制研究,研究重点为天然来源抗神经退行性疾病、抗病毒、抗肿瘤、抗代谢性疾病先导化合物的发现,以第一作者(或共一)或通讯作者发表SCI论文二十余篇,在Angewandte Chemie-International Edition、Journal of Medicinal Chemistry、Cell Communication and Signaling、Organic Letters、Journal of Natural Products、Marine Drugs等专业权威期刊发表论文三十余篇。主持国自基(青年)1项、国自基(面上)1项、湖北省科技重大专项子课题1项等课题。
1.联系方式
邮箱:weiguang_sun@hust.edu.cn
地址:武汉市硚口区航空路13号同济医学院新葡萄3522登录网页版1号楼334室邮编430030
2.研究方向
(1)天然药物活性评价、作用靶点反向虚拟筛选和机制研究
(2)基于蛋白质结构的药物设计与发现
3.教育与工作经历
2022/6~至今,我校,新葡萄3522登录网页版,副教授
2020/7~2022.5,我校,新葡萄3522登录网页版,讲师
2016/7~2020/6,我校,博士后,合作导师:张勇慧教授、王小川教授
2010/9~2016/6,我校,药物化学,博士,导师:张勇慧教授
4.主持科研项目
(1) 湖北省科技重大专项,创新药物筛选技术研发与集成/子课题1:先导化合物的筛选技术研发;2021/09-2023/08,200万元,在研,主持
(2) 国家自然科学基金面上基金,靶向PKCθ木质素类抑制剂的发现与结构优化及治疗自身免疫性肝炎活性研究;2022/01-2025/12,55万,在研,主持
(3) 国家自然科学基金青年基金,金线莲苷衍生物降糖活性和作用机制研究;2018.01-2020.12,20万,已结题,主持
(4) 主持国家重点研发计划,组合生物合成构建新骨架人工产物/子课题4:基于机器学习的成药分子设计及新骨架人工产物药效学评价;2021/12-2026/11,100万元,在研,课题骨干
(5) 我校人才引进基金,2020/09-2023/09,15万元,在研,主持
5.主要学术论文(#Co-first author,*Corresponding author)
(1) Shan Yan(#), Changxing Qi(#), Wei Song, Qianqian Xu, Lianghu Gu,Weiguang Sun(*), Yonghui Zhang(*). Marine Drugs 2021, 19, 588.
(2) Fengli Li, Zi Ye, Zhangyan Huang, Xia Chen,Weiguang Sun(#), Weixi Gao, Sitian Zhang , Fei Cao, Jianping Wang, Zhengxi Hu(#), Yonghui Zhang(#). Bioorganic Chemistry. 2021,117:105452.
(3) Weiguang Sun(#), Yanli Wu(#), Mengzhu Zheng(#), Yueying Yang , Yang Liu , Canrong Wu , Yirong Zhou(*), Yonghui Zhang(*), Lixia Chen(*), Hua Li(*). Journal of Medicinal Chemistry. 2020, 63(15):8146-8156.
(4) Mengting Liu(#),Weiguang Sun(#), Ling Shen, Yan He, Junjun Liu, Jianping Wang, Zhengxi Hu(*), Yonghui Zhang(*). Angewandte Chemie International Edition 2019, 58, 12091–12095.
(5) Liang Lei(#),Weiguang Sun(#), Long He, Hongfeng Jiang, Mingjin Zhang, Wenjuan He, Zhengxi Hu, Ye Gu, Hongping Song, Yonghui Zhang. Cardiotoxicity of Consolida rugulosa, a poisonous weed in Western China. Ecotoxicology and Environmental Safety. 2019,170:141-147
(6) Qin Li(#), Chunmei Chen(#), Mengsha Wei, Chong Dai, Li Cheng, Jiafeng Tao, Xiao-Nian Li, Jianping Wang,Weiguang Sun(*), Hucheng Zhu(*), and Yonghui Zhang(*). Organic Letters. 2019 ,21(7):2290-2293.
(7) Chunmei Chen,Weiguang Sun, Xiaorui Liu, Mengsha Wei, Yu Liang, Jianping Wang, Hucheng Zhu(*), Yonghui Zhang(*). Bioorganic Chemistry. 2019, 91:103166.
(8) Yi Zang, Yihua Gong, Xuwen Li, Xiaonian Li, Junjun Liu, Chunmei Chen, Yuanzhou, Lianghu Gu, Zengwei Luo, Jianping Wang,Weiguang Sun(*), Hucheng Zhu(*)and Yonghui Zhang(*). Organic Chemistry Frontiers. 2019, 6.
(9) Mengting Liu(#),Weiguang Sun(#), Jianping Wang(#), Yan He, Jinwen Zhang, Fengli Li, Changxing Qi, Hucheng Zhu, Yongbo Xue, Zhengxi Hu(*), Yonghui Zhang(*). Bioorganic Chemistry. 2018, 80, 525–530.
(10)Zhengxi Hu(#),Weiguang Sun(#), Fengli Li(#), Jiankun Guan(#), Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang(*), Hucheng Zhu(*), Yonghui Zhang(*). Organic Letters. 2018, 20, 5198–5202.
(11)Fengli Li(#),Weiguang Sun(#), Jiankun Guan(#), Yuanyuan Lu(#), Sitian Zhang, Shuang Lin, Junjun Liu, Weixi Gao, Jianping Wang, Zhengxi Hu(*), Yonghui Zhang(*). Organic Letters. 2018, 20, 7982–7986.
(12)Qing Zhang, Beiye Yang, Fengli Li, Mengting Liu, Shuang Lin, Jianping Wang, Yongbo Xue, Hucheng Zhu,Weiguang Sun(*), Zhengxi Hu(*), Yonghui Zhang(*). Marine Drugs. 2018, 16, 230.
(13)Keliang Chen(#), Xuwen Zhang(#),Weiguang Sun(#), Junjun Liu, Jing Yang, Chunmei Chen, Xiulan Liu, Limin Gao, Jianping Wang, Hua Li, Zengwei Luo, Yongbo Xue, Hucheng Zhu(*), and Yonghui Zhang(*). Organic Letters. 2017,19(21):5956-5959.