方进波,副教授,硕士研究生导师。主要从事(1)中药药效物质及作用机制;(2)中药质量控制方法研究。国家自然科学基金通讯评审专家,教育部硕士学位论文评审专家。人民卫生出版社药学统编教材《生药学》第7、8版编委,《生药学学习指导与习题集》(第1,2版)副主编。主持或参与国家自然科学基金、国家重大新药创制专项及国家重点研发计划等国家级项目多项,申请发明专利4项。在Phytomedicine, Planta Medica, Journal of Natural Products, Journal of Agricultural and Food Chemistry, Journal of Ethnopharmacology, Acta Pharmacologica Sinica等期刊发表论文30余篇。
办公室新葡萄3522登录网页版一号楼516.
Emailfangjb@hust.edu.cn.
课题组成员
彭会明德国Duisberg-Essen University分子生物学博士(2016)
张亚丽沈阳药科大学中药学硕士(2021)
工作经历
2011.11- 我校同济新葡萄3522登录网页版中药与天然药物学系,副教授
2012.8-2013.8美国University of Illinois Chicago/NIH Center for Botanical Dietary Supplements Research访问学者
2006.7-2011.10我校同济新葡萄3522登录网页版中药系,讲师
教育背景
2003.9-2006.7天津大学新葡萄3522登录网页版应用化学博士
2000.9-2003.7湖北中医学院中药学硕士
1996.9-2000.7湖北中医学院中药学学士
学术兼职
Chinese Medicine, Young Editorial BoardMember
世界中联李时珍医药研究与应用专业委员会常务理事
中国民族医药学会药用资源分会常务理事
中华中医药学会中药鉴定分会委员
科研项目
1.维药药效物质基础与临床新适应症的发现【2020.1-2025.12,主持】
2.黄连等三种鄂产高品质道地中药材规模化种植及精准扶贫示范研究【国家重点研发计划,NO.2017YFC1701000,2018.1-2022.12,参与】
3.香血藤生物活性成分及作用机制研究【波谱与原子分子物理国家重点实验室开放课题,T152602,2016.9-2018.9,主持】
4.基于PUF-MS的黑种草子中Keap 1抑制剂的快速发现【我校自主创新基金, 2016YXMS145,2016.1-2018.12,主持】
5.治疗2型糖尿病“消渴饮水”方的中药组分复方候选药物研究【湖北省技术创新专项重大项目,2016ACA141,2016.06-2018.12,参与】
6.药用植物香血藤调控NF-кB治疗类风湿关节炎的活性成分研究【国家自然科学基金,NO.31000150,2011.1-2013.12,主持】
7.湖北麦冬多糖片新药临床前研究【国家“重大新药创制”科技重大专项项目,NO.2011ZX09102-004-02,2011.01-2014.12,参与】
8.鄂产六种獐牙菜属植物抗糖尿病作用及资源品质研究【国家自然科学基金,NO.30970282,2010.01-2012.12,参与】
9.道地药材湖北麦冬中均一多糖降血糖功能与结构研究【国家自然科学基金,NO.30873373,2009.01-2011.12,参与】
学术会议
1.Jinbo Fang, Dejan Nikolić, Shao-Nong Chen, Rene F. Ramos Alvarenga, David C Lankin, Guido F. Pauli, and Richard B. van Breemen*, Structure Determination of 8-Prenylnaringenin Glucuronides Formed by Human Liver Microsomes(Abstracts),Planta Medica,2013,79(10):887,2013 Annual Meeting of The American Society of Pharmacognosy, St Louis, Missouri, United States, July 14 – 17.
2.中国中药协会第六届全国青年科学家中药质量与安全创新论坛执行主席,专题报告“中药质量评价的探索与实践-从药材到组分复方”,2022.9.3.
教材编写
1.生药学(人民卫生出版社,第7、8版,纸质版和数字教材),编委,2016,2021.
2.中药生物技术(人民卫生出版社,国家卫健委“十三五”中药专业规划教材,第1版),编委,2021.
3.生药学学习辅导与习题集(人民卫生出版社,第1版),副主编,2016.
4.生药学学习辅导与习题集(人民卫生出版社,第2版),副主编,2023.
5.生药学(案例版)(科学出版社,第3版),副主编,2024.
专利申请
1.方进波,叶茂,陈家春,吴宇星,一种治疗慢性盆腔炎的药物及其制备方法(ZL201110107353.8)
2.方进波,罗韬,李红钢,向槿,一种黄酮类化合物及其制备方法与应用(ZL202010250678.0)
3.方进波,张亚丽,彭会明,神香草挥发油的分析方法及在制备治疗激素抵抗性哮喘药物中的应用(ZL202111473843.X)
4.方进波,聂晶,彭会明,张亚丽,等,安格洛苷C或组合物用于制备治疗甲亢药物的应用(申请号: 2023103365266)
学术论文
1. Qilin Tong, Dan Luo, Zhinan Xiang, Yali Zhang, Jiaxin He, Zhuofan Hu, Rufeng Xia, Jiale Wu, Xiaona Fu, Qiang Li, Huiming Peng, Rong Huang, Luoshen Wan*, Jiachun Chen*,Jinbo Fang*. Metabolic profiling integrated with pharmacokinetics to reveal the material basis of Xiaokeyinshui extract combination in the treatment of type 2 diabetes in rats,Journal of Pharmaceutical and Biomedical Analysis, 2023, 225,115224.
2. Jin Xiang#, Hang Kang#, Hong-Gang Li#, Yu-Long Shi, Ya-Li Zhang, Chang-Lei Ruan, Lin-Hui Liu, Han-Qi Gao, Tao Luo, Gao-Sheng Hu, Wei-Liang Zhu, Jing-Ming Jia, Jia-Chun Chen,Jin-Bo Fang*,Competitive CatSper Activators of Progesterone fromRhynchosia volubilis,Planta Medica, 2022, 88(11): 881-890.
3. Ya-Li Zhang, Qiang Yin, Hui-Ming Peng, Rong Huang, Jie-Wen Zhou, Lin-Hui Liu, Han-Qi Gao, Chuan-Peng Zhao, Xin-Hang Peng, Ling Xiao, Jing Nie, Quan-Cheng Yang, Chun-Ye He, Gao-Sheng Hu, Jia-Chun Chen, Jing-Ming Jia*,Jin-Bo Fang*, Network pharmacology analysis and experimental validation to explore the mechanism ofHanchuan Zupa Granulein asthma,Journal of Ethnopharmacology, 2021, 281, 114534.
4. Zhinan Xiang, Haifei Xie, Qilin Tong, Jun Pan, Luosheng Wan*,Jinbo Fang*, Jiachun Chen*, Revealing hypoglycemic and hypolipidemic mechanism of Xiaokeyinshui extract combination on streptozotocin-induced diabetic mice in high sucrose/high fat diet by metabolomics and lipidomics,Biomedicine & Pharmacotherapy, 2021, 135, 111219.
5.Jin-Bo Fang, Dejan Nikolić, David C Lankin, Charlotte Simmler, Shao-Nong Chen, Rene F. Ramos Alvarenga, Yang Liu, Guido F. Pauli, and Richard B. van Breemen*, Formation of (2R)- and (2S)-8-Prenylnaringenin Glucuronides by Human UDP-Glucuronosyltransferases,Journal of Agricultural and Food Chemistry,2019,67 (42): 11650-11656.
6. Dan Liu, Qiang Yin, Qihua Zhang, Jin Xiang, Changlei Ruan, Huili Liu, Bo Li, Weiliang Zhu, Chun-ping Yin*,Jinbo Fang*, New NO production inhibitors fromHyssopus cuspidatusin LPS-induced RAW264.7 cells,Phytochemistry Letters, 2019, 34: 91-95.
7. Jing Nie1, Ling Xiao1, Lamei Zheng1, Zhifeng Du1, Dan Liu, Jiewen Zhou, Jin Xiang, Junjie Hou, Xiaogang Wang,Jinbo Fang*, An integration of UPLC-DAD/ESI-Q-TOF MS, GC-MS and PCA analysis for quality evaluation and identification of cultivars of Chrysanthemi Flos (Juhua),Phytomedicine, 2019,59,152803.
8. Yong-qin ZHOU, Xiu-fang WENG, Rui DOU, Xiao-sheng TAN, Tian-tian ZHANG,Jin-bo FANG*,Xiong-wen WU*, Betulin fromHedyotis hedyotideaameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice,Acta Pharmacologica Sinica,2017, 38(2):201-210.
9. Yan Xiang, Tiantian Zhang, Chunpin Yin, Jiewen Zhou, Rong Huang, Shasha Gao, Lamei Zheng,Xiaogang Wang, Anne Manyande, Xuebi Tian, Jiachun Chen,Jinbo Fang*, Effects of the stem extracts of Schisandra glaucescens Diels on collagen-induced arthritis in Balb/c mice,Journal of Ethnopharmacology, 2016,194:1078-1086.