孙伟光，博士，我校同济医学院新葡萄3522登录网页版副教授、博士/硕士生导师，生物药学系。主要从事植物与真菌来源天然产物的活行评价及作用机制研究，研究重点为天然来源抗自身免疫性性疾病、抗病毒、抗肿瘤、抗代谢性疾病等先导化合物的发现，以第一作者（或共一）或通讯作者在Acta Pharmaceutica Sinica B、Angewandte Chemie-International Edition、Journal of Medicinal Chemistry、Cell Communication and Signaling、Organic Letters、Journal of Natural Products、Marine Drugs等专业权威期刊发表论文四十余篇，入选湖北省楚天学子，任中国药理学会会员、湖北省晶体学会会员。主持国自基（青年）1项、国自基（面上）1项、湖北省科技重大专项子课题1项等课题。
【联系方式】
邮箱：weiguang_sun@hust.edu.cn
地址：武汉市硚口区航空路13号同济医学院转化大楼14楼1424室
邮编430030
【研究方向】
(1)天然药物活性评价、作用靶点反向虚拟筛选和机制研究
(2)基于蛋白质结构的药物设计与发现
【教育与工作经历】
2022/6~至今，我校，新葡萄3522登录网页版，副教授
2020/7~2022.5，我校，新葡萄3522登录网页版，讲师
2016/7~2020/6，我校，博士后，合作导师：张勇慧教授、王小川教授
2010/9~2016/6，我校，药物化学，博士，导师：张勇慧教授
【主持科研项目】
(1)湖北省科技重大专项，创新药物筛选技术研发与集成/子课题1：先导化合物的筛选技术研发；2021/09-2023/08，200万元，在研，主持
(2)国家自然科学基金面上基金，靶向PKCθ木质素类抑制剂的发现与结构优化及治疗自身免疫性肝炎活性研究；2022/01-2025/12，55万，在研，主持
(3)国家自然科学基金青年基金，金线莲苷衍生物降糖活性和作用机制研究；2018.01-2020.12，20万，已结题，主持
(4)主持国家重点研发计划，组合生物合成构建新骨架人工产物/子课题4：基于机器学习的成药分子设计及新骨架人工产物药效学评价；2021/12-2026/11，100万元，在研，课题骨干
(5)我校人才引进基金，2020/09-2023/09，15万元，在研，主持
【主要学术论文】
[1] Yulin Duan(#),Weiguang Sun(#), Yongqi Li(#), Zhengyi Shi, Lanqin Li, Yeting Zhang, Huang Kun, Zhiping Zhang, Changxing Qi(*), Yonghui Zhang(*). Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures.Acta Pharmaceutica Sinica B, 2024, online. (DOI: 10.1016/j.apsb.2024.02.002).
[2] Bo Tao(#), Yongqi Li(#), Yulin Duan(#), Zhengyi Shi, Jie Li, Yi Guo, Xinye Huang, Yeting Zhang,Weiguang Sun(*), Changxing Qi(*), Yonghui Zhang(*). Discovery of adamantane-type polycyclic polyprenylated acylphloroglucinols that can prevent concanavalin A-induced autoimmune hepatitis in mice.Bioorganic Chemistry, 2024, 144, 107145. (DOI: 10.1016/j.bioorg.2024.107145)
[3] Fei Liu(#), Xinyi Qiao(#), Qin Li, Jiajun Zhou, Jie Gao, Feng He, Peng Wu, Chunmei Chen,Weiguang Sun(*), Hucheng Zhu(*), Yonghui Zhang(*). Aculeatiols A−G: Lovastatin derivatives extracted fromAspergillus aculeatus.Journal of Natural Products, 2024, online. (DOI: 10.1021/acs.jnatprod.3c00872).
[4] Hong Hu(#), Lanqin Li(#), Zhengyi Shi(#), Xueqi Lan, Yeting Zhang, Xinye Huang, Xincai Hao, Qun Zhou,Weiguang Sun(*), Changxing Qi(*), Yonghui Zhang(*). Polyaspers A and B, the first ergosterol-polyether adducts with unprecedented 6/6/6/5/5/6/6/6/6 nonacyclic architecture fromAspergillussp. TJ507.Chinese Journal of Chemistry, 2024, 42, 743–751. (DOI: 10.1002/cjoc.202300649).
[5] Meijia Zheng, Chenxi Zhou, Hong Liao, Qin Li, Alan Bao, Chunmei Chen, Feng He, Peng Wu,Weiguang Sun(*), Hucheng Zhu(*), Yonghui Zhang(*).Enantiomeric α-pyrone derivatives with immunosuppressive activity fromTalaromyces adpressus.Phytochemistry, 2024, 218, 113931. (DOI: 10.1016/j.phytochem.2023.113931).
[6] Aimin Fu(#), Chunmei Chen(#), Qin Li(#), Nanjin Ding, Jiaxin Dong, Yu Chen, MengshaWei,Weiguang Sun(*), Hucheng Zhu(*), Yonghui Zhang(*). Niduenes A−F, six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungusAspergillus nidulans.Chinese Chemical Letters, 2023, 109100. (DOI: 10.1016/j.cclet.2023.109100).
[7] Yeting Zhang(#), Zhengyi Shi(#), Chunhua Zhao(#), Lanqin Li, Ming Chen, Yunfang Cao, Fengqing Wang, Bo Tao, Xinye Huang, Jieru Guo(*), Changxing Qi(*),Weiguang Sun(*), Yonghui Zhang(*). Amoenucles A−F, undescribed nucleoside derivatives with TNF-αinhibitory activities fromAspergillus amoenusTJ507.Chinese Journal of Natural Medicines, 2023, 22, 1–9. (DOI: 10.1016/S1875-5364(24)60570-4).
[8] Mengsha Wei(#),Weiguang Sun(#), Linlin Liu, Yongqi Li, Lanqin Li, Qin Li, Yu Chen, Jieru Guo, Lianghu Gu, Hucheng Zhu(*), Chunmei Chen(*), Yonghui Zhang(*). Ten ring-B aromatized ergosterols fromAspergillus spectabilis.Chinese Journal of Natural Medicines, 2023, 21, 1–9. (DOI: 10.1016/S1875-5364(23)60515-1).
[9] Yu Liang(#), Hong Liao(#), Xuanni Chen, Qiwei Wang, Qin Li, Yong Shen, Yuyi Zheng, Xiao-Nian Li, Hucheng Zhu, Dongyan Li(*),Weiguang Sun(*), Chunmei Chen(*), Yonghui Zhang(*). Pegriseofamines A–E: Five cyclopiazonic acid related indole alkaloids from the fungusPenicillium griseofulvum.Bioorganic Chemistry, 2023, 136, 106553. (DOI: 10.1016/j.bioorg.2023.106553).
[10] Qin Li, Meijia Zheng, Fengli Li, Yongqi Li, Chunmei Chen, Zijian Huang, Junjun Liu,Weiguang Sun(*), Ying Ye(*), Hucheng Zhu(*), Yonghui Zhang(*). Talarolactones A–G,α-pyrone dimers with anti-inflammatory activities fromTalaromyces adpressus, and their biosynthetic pathways.Organic Letters, 2023, 25, 1616–1621. (DOI: 10.1021/acs.orglett.2c04352).
[11] Yu Liang(#), Lanqin Li(#), Yong Shen, Yuyi Zheng, Qin Li, Qingyi Tong, Qun Zhou, Xiao-Nian Li, Dongyan Li, Hucheng Zhu,Weiguang Sun(*), Chunmei Chen(*), Yonghui Zhang(*). Four undescribed ergostane-type steroids fromLasiodiplodia pseudotheobromaeand their neuroprotective activity.Phytochemistry, 2022, 201, 113248. (DOI: 10.1016/j.phytochem.2022.113248).
[12] Qianqian Xu(#), Yanfang Deng(#), Jiaxiong Ming, Zengwei Luo, Xia Chen, Tianqi Chen, Yafen Wang, Shan Yan, Jiajun Zhou, Lina Mao,Weiguang Sun(*), Qun Zhou(*), Hong Ren(*), Yonghui Zhang(*). Methyl 6-O-cinnamoyl-α-d-glucopyranoside ameliorates acute liver injury by inhibiting oxidative stress through the activation of Nrf2 signaling pathway.Frontiers in Pharmacology, 2022, 13: 873938. (DOI: 10.3389/fphar.2022.873938).
[13] Limin Gao, Xingyu Chen, Zeyu Fu, Jie Yin, Yafen Wang,Weiguang Sun(*), Hong Ren(*), Yonghui Zhang(*).Kinsenoside alleviates alcoholic liver injury by reducing oxidative stress, inhibiting endoplasmic reticulum stress, and regulating AMPK-dependent autophagy,Frontiers in Pharmacology, 2022, 12, 747325. (DOI: 10.3389/fphar.2021.747325).
[14] Fengli Li, Zi Ye, Zhangyan Huang, Xia Chen,Weiguang Sun(*), Weixi Gao, Sitian Zhang, Fei Cao, Jianping Wang, Zhengxi Hu(*),Yonghui Zhang(*). Newα-pyrone derivatives with herbicidal activity from the endophytic fungusAlternaria brassicicola.Bioorganic Chemistry,2021, 117, 105452. (DOI: 10.1016/j.bioorg.2021.105452).
[15] Shan Yan(#), Changxing Qi(#), Wei Song, Qianqian Xu, Lianghu Gu,Weiguang Sun(*), Yonghui Zhang(*). Discovery of GOT1 inhibitors from a marine-derivedAspergillus terreusthat act against pancreatic ductal adenocarcinoma.Marine Drugs,2021, 19, 588. (DOI: 10.3390/md19110588).
[16] Weiguang Sun(#), Yanli Wu(#), Mengzhu Zheng(#), Yueying Yang, Yang Liu, Canrong Wu, Yirong Zhou(*), Yonghui Zhang(*), Lixia Chen(*), Hua Li(*). Discovery of an orally active small-molecule tumor necrosis factor‑αinhibitor.Journal of Medicinal Chemistry, 2020, 63, 8146−8156. (DOI: 10.1021/acs.jmedchem.0c00377).
[17] Fengli Li(#),Weiguang Sun(#), Sitian Zhang(#), Weixi Gao, Shuang Lin, Beiye Yang, Chenwei Chai, Huaqiang Li, Jianping Wang, Zhengxi Hu(*), Yonghui Zhang(*). New cyclopiane diterpenes with anti-inflammatory activity from the sea sediment-derived fungusPenicilliumsp. TJ403-2.Chinese Chemical Letters,2020, 31, 197–201. (DOI: 10.1016/j.cclet.2019.04.036).
[18] Weiguang Sun(#), Shanshan Luan(#), Changxing Qi(#), Qingyi Tong, Shan Yan, Hua Li(*), Yonghui Zhang(*). Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism.Cell Communication and Signaling, 2019, 17, 111.(DOI: 10.1186/s12964-019-0425-4).
[19] Mengting Liu(#),Weiguang Sun(#), Ling Shen, Yan He, Junjun Liu, Jianping Wang, Zhengxi Hu(*), Yonghui Zhang(*). Bipolarolides A–G, ophiobolin-derived sesterterpenes representing three new carbon skeletons fromBipolarissp. TJ403-B1.Angewandte Chemie International Edition, 2019, 58, 12091–12095. (DOI: 10.1002/anie.201905966).
[20] Liang Lei(#),Weiguang Sun(#), Long He, Hongfeng Jiang, Mingjin Zhang, Wenjuan He, Zhengxi Hu, Ye Gu, Hongping Song(*), Yonghui Zhang(*). Cardiotoxicity of consolida rugulosa, a poisonous weed in Western China.Ecotoxicology and Environmental Safety, 2019, 170, 141–147. (DOI: 10.1016/j.ecoenv.2018.11.109).
[21] Qin Li(#), Chunmei Chen(#), Mengsha Wei, Chong Dai, Li Cheng, Jiafeng Tao, Xiao-Nian Li, Jianping Wang,Weiguang Sun(*), Hucheng Zhu(*), Yonghui Zhang(*). Niduterpenoids A and B: two sesterterpenoids with a highly congested hexacyclic 5/5/5/5/3/5 ring system from the fungusAspergillus nidulans.Organic Letters, 2019, 21, 2290−2293. (DOI: 10.1021/acs.orglett.9b00581).
[22] Fengli Li(#),Weiguang Sun(#), Jiankun Guan(#), Yuanyuan Lu(#), Sitian Zhang, Shuang Lin, Junjun Liu, Weixi Gao, Jianping Wang, Zhengxi Hu(*), Yonghui Zhang(*). Alterbrassicicene A, a highly transformed fusicoccane-derived diterpenoid with potent PPAR-γagonistic activity fromAlternaria brassicicola.Organic Letters, 2018, 20, 7982–7986. (DOI: 10.1021/acs.orglett.8b03553).
[23] Fengli Li(#),Weiguang Sun(#), Jiankun Guan(#), Yuanyuan Lu, Shuang Lin, Sitian Zhang, Weixi Gao, Junjun Liu, Guang Du, Jianping Wang, Hucheng Zhu, Changxing Qi(*), Zhengxi Hu(*), Yonghui Zhang(*). Anti-inflammatory fusicoccane-type diterpenoids from the phytopathogenic fungusAlternaria brassicicola.Organic & Biomolecular Chemistry, 2018, 16, 8751–8760. (DOI: 10.1039/c8ob02353k).
[24] Zhengxi Hu(#),Weiguang Sun(#), Fengli Li(#), Jiankun Guan(#), Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang(*), Hucheng Zhu(*), Yonghui Zhang(*).Fusicoccane-derived diterpenoids fromAlternaria brassicicola: Investigation of the structure-stability relationship and discovery of a IKKβinhibitor.Organic Letters, 2018, 20, 5198−5202. (DOI: 10.1021/acs.orglett.8b02137).
[25] Keliang Chen(#), Xuwen Zhang(#),Weiguang Sun(#), Junjun Liu, Jing Yang, Chunmei Chen, Xiulan Liu, Limin Gao, Jianping Wang, Hua Li, Zengwei Luo, Yongbo Xue, Hucheng Zhu(*), Yonghui Zhang(*). Manginoids A−G: seven monoterpene-shikimate-conjugated meroterpenoids with a spiro ring system fromGuignardia mangiferae.Organic Letters, 2017, 19, 5956−5959. (DOI: 10.1021/acs.orglett.7b02955).
