史琛 我校附属协和医院 药学部 副主任
医学博士、副主任药师、硕士生导师
主要从事
药物递送系统联合抗肿瘤治疗、抗肿瘤药理、临床药学（抗肿瘤方向）
主要课题成果论著
主持国家自然科学基金及湖北省自然科学基金6项、参与国家、省及市级课题15余项，获得湖北省科技进步二等奖一项；发表学术论文60余篇，其中SCI收录20余篇；参编、参译论著7部,获批实用新型专利1项，受理发明专利2项。
科研活动
德国Saarland-Universität生物药学系
德国Philipps-Universität Marburg生物药学系
学术任职
中国医师协会药事管理专业委员会 委员
中华医学会细菌感染与耐药防治分会（BISC）青年委员
中国老年保健医学研究会药事管理与药学创新分会 委员
中国药典委员会药品标准与临床应用委员会 委员
湖北省药学会 理事
湖北省药学会医院药学专业委员会 常务委员
湖北省医学会临床药学分会 委员
《中国医院药学杂志》通讯编委
《J Microencapsul》编委
AJHP中文版 青年编委
科研项目
（1）国家自然科学基金面上项目(主持)高仿生纳米系统靶向清除CAF及衰老CAF改善乳腺癌放疗抵抗的作用及机制研究
（2）国家自然科学基金青年项目(主持) 基于“二次破坏”效应构建具磁-药协同作用的纳米载体及其抗三阴乳腺癌的研究
（3）湖北省自然科学基金面上项目(主持) 远程磁控释药纳米粒靶向阻断TASK-3通道治疗三阴乳腺癌的实验研究
（4） 湖北省自然科学基金(主持) Anti-CD64/磁性PLGA纳米粒特异性靶向清除炎性巨噬细胞治疗类风湿性关节炎的实验研究
（5）湖北省卫生健康委青年人才项目（主持）应用益生菌改善中重度癌痛患者阿片耐受的临床研究
（6）湖北省卫健委中医药科研项目面上项目（主持）粉防己碱协同FR-PLGA MNPs调控TASK-3通道抑制三阴乳腺癌细胞增殖的实验研究
（7）“白求恩·求索-药学科研能力建设”项目（主持）替雷利珠单抗注射液上市后安全性再评价和经济学评价——基于真实世界数据
（8）中华国际医学交流基金会中青年医学研究专项基金项目（主持）益生菌通过调节肠道菌群改善癌痛患者阿片耐受的临床研究
（9）吴阶平医学基金会临床科研专项资助基金项目（主持）信迪利单抗注射液上市后安全性再评价和经济学评价-基于真实世界数据
（10）湖北省重点研发计划项目任务书(第一参与人)基于多组学的器官移植免疫抑制精准用药技术研发及应用
（11）国家自然科学基金面上项目(第一参与人) “远程释药可控性”骨靶向纳米载药系统介导雌激素治疗绝经后骨质疏松症的实验研究
（12）国家自然科学基金面上项目(第一参与人) 基于间充质干细胞外泌体实现骨质疏松症的骨靶向"精准"治疗 国家自然科学基金面上项目2019.8
（13）奥硝唑注射剂安全性评价数据分析 湖北省药品（医疗器械）不良反应监测中心（负责）2015.6
（14）特异靶向性Anti-CD64/磁性PLGA纳米粒在旋转磁场下诱导RA滑膜巨噬细胞凋亡的实验研究 生物靶向重点实验室(主持) 2016.3
论文代表作
(1) Yuanyuan Guo(#), Yongwei Liu(#),Chen Shi(#), Tingting Wu, Yongzhi Cui, Siyuan Wang, Ping Liu,Xiaobo Feng, Yu He& Dehao Fu，Remote-controllable bone-targeted delivery of estradiol for the treatment of ovariectomy-induced osteoporosis in rats, Journal of Nanobiotechnology, 2021 19: 248.
(2) Zhiwen Fu 1,2 , Liu Wang 1,2 , Shijun Li 1,2 , Fen Chen 1,2 , Kathy Ka-Wai Au-Yeung 3 * andChen Shi 1,2*. MicroRNA as an important target for anticancer drug development. Frontiers in Pharmacology. 2021, DOI:10.3389/fphar.2021.736323.
(3) Qilin Zhanga,b#, Xiaocui Liuc#, Mitchell A. Sullivand,Chen Shi a,b*,Bin Denga,b*, Protective Effect of Yi Shen Pai Du Formula Against Diabetic Kidney Injury via Inhibition of Oxidative Stress, Inflammation and Epithelial to Mesenchymal Transition in db/db Mice. Oxidative Medicine and Cellular Longevity, 2021
(4) Jinmei Liu ,1,2 Ming Zhang,3 Juan Luo,1,2 Jiyi Xie,1,2 Xu Chen,1,2 Hanxiang Wang,1,2 Shijun Li,1,2 Shengli Yang ,4 Chunfen Peng,4 Liangle Yang,5 Bin Deng,1,2 Yu Zhang,1,2 Cong Wang ,1,2* Jianli Hu ,4* andChen Shi 1,2*,Practice, Knowledge, and Attitude of Health Care Providers regarding Cancer Pain Management: A National Survey，Pain Research and Management.https://doi.org/10.1155/2021/1247202.
(5)Chen Shi1,2,†, Cong Wang1,† , Hanxiang Wang1,†, Chao Yang3 , Fei Cai3 , Fang Zeng1 , Fang Cheng1 , Yihui Liu1 , Taotao Zhou1 , Bin Deng1 , Israel Vlodavsky4 , Jin-Ping Li5 and Yu Zhang1,2,*. The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID-19 Patients: A Retrospective Cohort Study. Clin Transl Sci (2020) 0, 1–9; doi:10.1111/cts.12880
(6)Chen Shi a,b,1, Tingting Wua,b,1 , Jin-Ping Li c , Mitchell A. Sullivan d , Cong Wang a,b , Hanxiang Wang a , Bin Deng a,b, *, Yu Zhang a,b, *.Comprehensive Landscape of Heparin Therapy for COVID-19.2020, https://doi.org/10.1016/j.carbpol.2020.117232
(7) Qianyuan He1,2, Huiping Hu1, Qian Zhang3, Tingting Wu1, Yu Zhang1,4, Ke Li1,4*andChen Shi1,4*.Ultra-dispersed MnO2 fabricated by controlled etching as a biomimetic nanoplatform for enhanced photodynamic therapy and immune activation，Chemical Engineering Journal 397 (2020) 125478
(8)Yu Zhang a,b,1 , Huiping Hu c,1 , Wenqi Tang c , Qian Zhang d , Min Li e , Honglin Jin f , 4,Zi Huang c , Zheng Cui a , Jingya Xu c , Kaiping Wang c,* ,Chen Shi a,b,*. A multifunctional magnetic nanosystem based on "two strikes"effect for synergistic anticancer therapy in triple-negative breast cancer，Journal of Controlled Release, Volume 322,10 June 2020,Pages 401-415. Doi:10.1016/j.jconrel.2020.03.036.
(9) Tingting Wu a, b, #, Qian Zhang c, #, Huiping Hu d, Fang Yang e, Ke Li a, Yu Zhang a andChen Shi a,b*. Enhancing cellular morphological changing and ablation of cancer cells via interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields，RSC Adv., 2020, 10, 14471–14481
(10)Chen Shi#, Tingting Wu#, Yu He, Yu Zhang, Dehao Fu*. Recent advances in bone-targeted therapy. Pharmacology & Therapeutics 2020 Mar;207:107473. doi: 10.1016/j.pharmthera.2020.107473.
（11）Wang K, Hu H, Zhang Q, Zhang Y,Shi C*. Synthesis, purification, and anticancer effect of magnetic Fe3O4-loaded poly (lactic-co-glycolic) nanoparticles of the natural drug tetrandrine. J Microencapsul. 2019 Jun;36(4):356-370.
（12）XiaoLi Hua, Ming Gu, Fang Zeng, Huiping Hu, Tao Zhou, Yu Zhang*,Chen Shi *.Pharmacy administration and pharmaceutical care practice in a module hospital during the COVID-19 epidemic. Journal of the American Pharmacists Association 2020, 1-8. https://doi.org/10.1016/j.japh.2020.04.006
（13）Jinmei Liu, Cong Wang, Xu Chen, Juan Luo, Jiyi Xie, Shijun Li, Jianli Hu,Chen Shi *.Evaluation of pharmacist interventions as part of a multidisciplinary cancer pain management team in a Chinese academic medical center. Journal of the American Pharmacists Association 2019,1-5, https://doi.org/10.1016/j.japh.2019.09.005
（14）Ying ZHAO , Pu HUANG , Siwei ZHENG , Qiling XU,Chen SH#.Analysis of ornidazole injection in clinical use at the post-marketing stage by hospital centralized monitoring. Current Medical Science, 39(5):836-842,2019.
（15）Chen Shi, Ping Liu , Yu He , Yongwei Liu ,Xiaobo Feng and Dehao Fu. Drug-loaded poly( D , L -lactide-co-glycolide) microspheres as treatment for allergic contact dermatitis in mice model,Journal of Bioactive and Compatible Polymers,.2017,32(5):445-455
（16）Shi C, Huang Pu, Zhao Y. Clinical application analysis of andrographolide total ester sulfonate injection, a traditional Chinese medicine licensed in China. J Huazhong Univ Sci Technol［Med Sci］.2017, 37(2): 293-299.
(17)Chen Shi, Carolin Thum, Marc Schneider,et al. Inhibition of the cancer-associated TASK 3 channels by magnetically induced thermal release of Tetrandrine from a polymeric drug carrier，Journal of Controlled Release, 237 (2016) 50–60.
(18)Chen Shi，Saeed Ahmad Khan，Kaiping Wang，Marc Schneider . Improved delivery of the natural anticancer drug tetrandrine，International Journal of Pharmaceutics，2015，479（1）：41-51.
(19)Chen Shi，He Y，Feng X，Fu D.ε-Polylysine and next-generationdendrigraft poly-L-lysine:chemistry, activity, and applications in biopharmaceuticals，Journal of Biomaterials Science, Polymer Edition，2015，26（18）：1343-1356.
(20) Chen Shi，Ping Liu，Xianzhe Liu，Xiaobo Feng，Dehao Fu. The effects of mPEG proportion and LA/GA ratio on degradation and drug release behaviors of PLGA-mPEG microparticles, Pharmazie 71: 243–246 (2016)
(21)Shi C, Zeng F, Fu D. Surfactant-free Poly (lactide-co-glycolide) Nanoparticles for Improving In Vitro Anticancer Efficacy of Tetrandrine, J Microencapsul. 2016 Mar 10:1-8.
(22) Meng R, Li K, Chen Z,Shi C. Multilayer Coating of Tetrandrine-loaded PLGA Nanoparticles: Effect of Surface Charges on Cellular Uptake Rate and Drug Release Profile. J Huazhong Univ Sci Technol［Med Sci］.2016, 35(6): 14-20.
(23)Chen S, Feng S, Liu P, Liu X, Feng X, Fu D. A novel study on the mechanisms of drug release in PLGA-mPEG microspheres with fluorescent drug. J Biomater Sci Polym Ed. 2016 Mar 16: (1-23）
联系方式：027-85726192 E-mails: whxhchen@163.com
通讯地址：武汉市解放大道1277号 我校附属协和医院药学部430022
