杜支凤,1987年4月,女,博士,我校副教授,从事质谱分析和生物无机化学、金属抗肿瘤药物作用机理方面的研究,目前已发表SCI论文8篇。
主要研究兴趣与方向:质谱分析,金属药物分子作用机理、药物与生物分子的相互作用、蛋白质组学。
教育背景
2005.9-2009.6 武汉大学药学专业毕业,获理学学士学位
2009.9-2014.6 中国科学院化学研究所分析化学专业毕业,获理学博士学位
工作经历
2014.9–2016.12美国弗吉尼亚联邦大学化学系博士后
发表论文
1. Du, Z.; Luo, Q.; Yang, L.; Bing, T.; Li, X.; Guo, W.; Wu, K.; Zhao, Y.; Xiong, S.; Shangguan, D.; Wang, F., Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex. J. Am. Chem. Soc. 2014,136 (8), 2948-2951.
2. Du, Z.; de Paiva, R. E. F.; Qu, Y.; Farrell, N., Tuning the reactivity of Sp1 zinc fingers with platinum complexes. Dalton Trans. 2016,45, 8712-8716.
3. Du, Z.; de Paiva, R. E. F.; Nelson. K; Farrell, N., Diversity in Gold Finger Structure elucidated by Traveling-Wave Ion Mobility Mass Spectrometry. Angew. Chem. Int. Ed.2017, 56 (16), 4464-4467.
4. Xia, W.; Du, Z.; Cui, Q.; Dong, H.; Wang, F.; He, P.; Tang, Y., Biosurfactant produced by novel Pseudomonas sp. WJ6 with biodegradation of n-alkanes and polycyclic aromatic hydrocarbons. J. Hazard. Mater. 2014,276, 489-498.
5. Bernardes, V. H. F.; Qu, Y.; Du, Z.; Beaton, J.; Vargas, M. D.; Farrell, N. P., Interaction of the HIV NCp7 Protein with Platinum(II) and Gold(III) Complexes Containing Tridentate Ligands. Inorg. Chem. 2016.55, 11396-11407.
6. Zhang, G.; Hu, W.; Du, Z.; Lv, S.; Zheng, W.; Luo, Q.; Li, X.; Wu, K.; Han, Y.; Wang, F., A comparative study on interactions of cisplatin and ruthenium arene anticancer complexes with metallothionein using MALDI-TOF-MS.Int. J. Mass spectrom. 2011,307 (1–3), 79-84.
7. Zheng, W.; Luo, Q.; Lin, Y.; Zhao, Y.; Wang, X.; Du, Z.; Hao, X.; Yu, Y.; Lu, S.; Ji, L.; Li, X.; Yang, L.; Wang, F., Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis. Chem. Commun. 2013,49 (87), 10224-10226.
联系方式:
Email: zhifengdu11@163.com
地址:湖北省武汉市航空路13号我校同济医学院新葡萄3522登录网页版2号楼,430030