姚广民，男，博士，山东省东明县人。现任我校同济医学院新葡萄3522登录网页版教授、博士生导师，中国科学院新疆理化技术研究所客座研究员。入选湖北省“楚天学者”计划、新疆自治区高层次人才工程。主要从事天然药物化学与创新药物的研究与开发。先后主持国家自然科学基金等各类科研项目27项，指导国家级和校级大学生创新性实验计划20余项。在JACS、NPR等期刊上发表论文140余篇。承担本科生《波谱解析》、《天然药物化学》、《天然药物化学实验》；研究生《结构解析》、《药学论文写作》；博士生《药物立体化学》；留学生《Natural Medicinal Chemistry》等课程教学。硕/博士研究生招生专业方向：药物化学（含天然药物化学）、中药与天然药物学。
通讯地址：湖北省武汉市航空路13号，我校同济医学院，新葡萄3522登录网页版1号楼，邮编430030，电话：15171484550，E-mail：gyap@mail.hust.edu.cn
教育背景及工作经历
2014/11–至今，我校，同济医学院新葡萄3522登录网页版，教授，硕士生/博士生导师。
2009/5–2014/10，我校，同济医学院新葡萄3522登录网页版，副教授，硕士生/博士生导师。
2007/12–2009/5，美国夏威夷太平洋大学，博士后。
2006/02–2007/12，美国明尼苏达大学，博士后。
2005/07–2006/02，石药集团中奇制药技术（石家庄）有限公司，项目组长。
2002/9–2005/7，中国科学院，上海药物研究所，博士。
1999/9–2002/7，南开大学，元素有机化学研究所，硕士。
荣誉与学术兼职
湖北省“楚天学者”'、新疆维吾尔自治区高层次人才、湖北省科技厅权威专家库高端专家、湖北省药监局药品科技咨询专家、中国民族医药学会科研分会常务理事、中国民族医药学会药用资源分会常务理事、《中国化学快报》第三届/第四届青年编委、湖北省“三区”人才支持计划科技人员、湖北省“院士专家企业行”专家人选、科技部、国家基金委、教育部、湖北/湖南/陕西/海南/江西/广西等省多种科研项目和人才项目评审专家、Chemical Science、OL、CCL、CJC等多个SCI期刊审稿人。
研究方向
天然药物化学与创新药物的研究与开发。主要是从传统中草药、药用植物等天然药物资源中寻找结构新颖、具有显著生物活性的天然产物，并以此为先导化合物，通过化学结构改造、结构优化等方法从中发现高效低毒的新药候选化合物，开发出具有自主知识产权的创新药物。目前正在系统开展杜鹃花科、石蒜科葱莲属、唇形科鼠尾草属和樟科樟属等药用植物中的活性成分及其作用机制。从中发现了具有显著抗血栓、镇痛、PTP1B抑制、免疫调节、抗肿瘤、抗炎等生物活性的化合物三千多个，新化合物一千多个，并对其作用机制进行探讨，为创新药物研究奠定基础。
主持科研项目情况
(1)国家自然科学基金面上项目，两种鄂产马醉木属植物中新颖PDI抑制剂的发现及其抗血栓活性研究，22277034，2023.1-2026.12，54万元。
(2)国家自然科学基金联合基金（NSFC-新疆联合基金），U1703109，两种新疆特有药用植物中抗MIRI活性成分研究。2017.1-2020.12，60万元。
(3)国家科技部“重大新药创制专项”，2013ZX09103-001-020，化药1类治疗高脂血症CETP抑制剂TRZ候选药物研究。2013.1-2015.12，114.52万元。
(4)国家自然科学基金面上项目，31170323，两种石蒜科葱莲属药用植物中抗肿瘤生物碱活性成分及其作用机制研究。2012.1-2015.12，50万元。
(5)国家自然科学基金青年科学基金，81001368，基于抑制Streptomyces85E气生菌丝生成从照山白中寻找新颖的蛋白激酶抑制剂先导化合物。2011.1-2013.12，22万元。
(6) 2020年新疆自治区高层次人才工程，2021-254，基于多靶点策略从新疆特色药用植物中发现降血糖活性先导化合物，2021.1-2023.12，30万元。
(7)新疆特色药食用植物资源化学实验室（喀什大学）开放基金，KSUZDSYS202101，新疆鼠尾草地上部分抗MIRI活性成分及其调控PI3K/Akt通路的作用机制研究，2022.1-2024.12，10万元。
(8)植物化学与西部植物资源持续利用国家重点实验室（中国科学院昆明植物研究所）开放基金，P2022-KF08，美丽马醉木中新颖二氢查耳酮二聚体的发现及其靶向蛋白质二硫键异构酶的抗血栓活性研究，2022.5-2024.5，8万元。
(9)恩施州科技计划项目，D20210028，基于抑制PDI作用的富硒抗血栓功能食品研发。2021.7-2023.6，7.5万元。
(10) 2020年科技人员服务企业专项行动·湖北专项（第二批）恩施硒禾生物科技有限公司委托项目，202101，富硒药食同源植物功能性食品研发。2021.1-2021.12，10.5万元。
(11)茶树生物学与资源利用国家重点实验室（安徽农业大学）开放基金，SKLTOF20210109，湖北红茶“利川红”中新颖蛋白二硫键异构酶（PDI）抑制剂的发现及其抗血栓活性研究。2021.10-2023.9。6万元。
(12)湖北省卫生健康委员会，中医药科研项目，ZY2021M056，基于NLRP3炎症小体信号通路的恩施黄柏抗炎物质基础和机制研究。2021.1-2022.12。5万元。
(13)省部共建药用资源化学与药物分子工程国家重点实验室（广西师范大学）开放基金，CMEMR2021-B02，广西肉桂子中新颖免疫调节剂的发现及其作用机制研究。5万元。
(14)湖北省农业科学院中药材研究所委托项目，2019，2019.7-2020.7，湖北贝母化学成分研究。5万元。
(15)恩施硒禾生物科技有限公司委托项目，2019，新有机硒化合物的发现与功能研究。20万元。
(16)药物化学生物学国家重点实验室（南开大学）开放基金，2018063，鄂产羊踯躅叶中新颖PTP1B抑制剂先导化合物的发现研究。3万元。
(17)中国科学院干旱区植物资源化学实验室（中国科学院新疆理化技术研究所）开放基金，2008DP173091-2016-01，维药肉桂子化学成分及其免疫调节活性研究。12万元。
(18)我校自主创新基金，2016YXMS148，鄂产羊踯躅中抗肾间质纤维化活性成分研究。4万元。
(19)我校自主创新基金，2014QN131，两种樟科樟属药用植物化学成分和生物活性研究。4万元。
(20)我校自主创新基金，2012QN003，两种唇形科鼠尾草属药用植物化学成分和生物活性研究。4万元。
(21)武汉市青年科技晨光计划，201271031389，葱莲中抗肿瘤活性生物碱成分及其作用机制研究。10万元。
(22)教育部留学回国人员科研启动基金，第40批，新颖蛋白激酶抑制剂的发现研究。4万元。
(23)教育部高等学校博士学科点专项科研基金（新教师类），20100142120069，基于抑制Streptomyces85E气生菌丝生成从照山白中寻找新颖的蛋白激酶抑制剂先导化合物。3.6万元。
(24)湖北省卫生厅青年科技人才项目，QJX2010-2，基于抑制Streptomyces85E气生菌丝生成从山藿香中寻找新颖的蛋白激酶抑制剂先导化合物。4万元。
(25)湖北省自然科学基金，2010CDB03206，照山白中新颖蛋白激酶抑制剂先导化合物的筛选与评价。2万元。
(26)我校医科科研基金，2010-14，基于抑制Streptomyces85E气生菌丝生成从黄芫花中寻找新颖的蛋白激酶抑制剂先导化合物。1万元。
(27)天然药物化学与资源评价湖北省重点实验室(我校)开放基金，2010-3，地埂鼠尾草中蛋白激酶抑制剂先导化合物的发现研究。1万元。
(28)湖北省楚天学者计划，2011年，天然药物化学。
近十年（2012年后）代表性论文（#共同第一作者，*通讯作者，年代倒序）
(1) Guijuan Zheng, Keyu Lv, Hao Wang, Lang Huang, Yuanyuan Feng, Biao Gao, Yenan Sun, Yaofeng Li, Jiangeng Huang, Pengfei Jin, Xulin Xu,F. David Horgen, Chao Fang*,Guangmin Yao*.Piericones A and B as Potent Antithrombotics: Nanomolar Noncompetitive Protein Disulfide Isomerase Inhibitors with an Unexpected Chemical Architecture.Journal of American Chemical Society2023,145(5), 3196–3203.(IF: 16.383)
(2)Li Li#, Xulin Xu#, Keyu Lv, Guijuan Zheng, Hao Wang, Shuai Chen, Lang Huang, Yi Liu, Yadong Zhang, Zhaoming Tang, Lili Zhang, Jinyu Wang, Jianlin Qiao, Hongliang Li, Xuanbin Wang,Guangmin Yao*, Chao Fang*. Asebogenin suppresses thrombus formation via inhibition of Syk phosphorylation.British Journal of Pharmacology2023,180(3), 287–307.(IF:9.473)
(3)Chen-Hui Chen, Jing-Ya Yu, Zi Yang, Jia-Ping Ke, Yan Qi, Yi Yang, Biao Gao,Guangmin Yao, Guan-Hu Bao*. Novel methylated flavoalkaloids from Echa 1 green tea inhibit fat accumulation and enhance stress resistance inCaenorhabditis elegans.Food Chemistry2023,413,135643.(IF: 9.231)
(4) Yuanyuan Feng, Suqin Zha, Hanqi Zhang, Biao Gao, Pengfei Jin, Guijuan Zheng, Yingyi Chen, andGuangmin Yao*.Rhodauricanol A,an analgesic diterpenoid with an unprecedented 5/6/5/7 tetracyclic system featuring a unique 16-oxa-tetracyclo[11.2.1.01,5.07,13]hexadecane core fromRhododendron dauricum.Chinese Chemical Letters2023,34(4),107742(IF: 8.455)
(5)Yuanyuan Feng#, Hanqi Zhang#, Biao Gao, Guijuan Zheng,Suqin Zha, andGuangmin Yao*.Highly oxygenated grayanane diterpenoids with structural diversity from the flowers ofRhododendron dauricumand their analgesic activities.Bioorganic Chemistry2023,132,106374.(IF 5.307)
(6)Guanqun Zhan#, Biao Gao#, Junfei Zhou, Tingting Liu, Guijuan Zheng, Zhong Jin,Guangmin Yao*.Structurally diverse alkaloids with nine frameworks fromZephyranthes candidaand their acetylcholinesterase inhibitory and anti-inflammatory activities.Phytochemistry2023,207, 113564.(IF: 4.004)
(7)Jia-Ping Ke, Jing-Ya Yu, Biao Gao, Feng-Lin Hu, Feng-Qing Xu,Guangmin Yao, Guan-Hu Bao*. Two new catechins from Zijuan green tea enhance the fitness and lifespan ofCaenorhabditis elegansvia insulin-like signaling pathways.Food & Function2022,13(18), 9299–9310.(IF: 6.317).
(8)Yuanyuan Feng, Suqin Zha, Biao Gao, Hanqi Zhang, Pengfei Jin, Guijuan Zheng, Yilin Ma, andGuangmin Yao*.Discovery of kalmane diterpenoids as potent analgesics from the flowers ofRhododendron dauricum.Chinese Journal of Chemistry2022,40, 1019–1027.(IF: 5.560)
(9)Lang Huang#,Guijuan Zheng#, Yuanyuan Feng, Pengfei Jin, Biao Gao, Hanqi Zhang, Xiaomin Ma, Junfei Zhou,Guangmin Yao*.Highly oxygenated dimeric grayanane diterpenoids as analgesics:TRPV1 and TRPA1dualantagonists fromRhododendron molle.Chinese Journal of Chemistry2022,40, 2285–2295. (IF:5.560)
(10)Lei Zhou#, Gui-Juan Zheng#, Heng Li#, Biao Gao, Yindengzhi Guoruoluo, Wei Tang*,Guangmin Yao*, Yonghui Zhang*.Highly oxygenated isoryanodane diterpenoids from the leaves ofCinnamomum cassiaand their immunomodulatory activities.Phytochemistry2022,196,113077.(IF: 4.004)
(11)Lei Zhou, Gui-Juan Zheng, Peng-Fei Jin, Zheng-Xi Hu,Guang-Min Yao*, Yong-Hui Zhang*. A new megastimane sesquiterpenoid from the leaves ofCinnamomum cassia.Journal of Asian Natural Products Research2022,24(9), 877–883.(IF: 1.610)
(12) JIN Pengfei, ZHENG Guijuan1, HUANG Lang, YUAN Xinghua, MA Xiaomin, ZHAN Guanqun, ABUDUREXITI Adila*, YAO Guangmin. Analgesic monoterpene indole alkaloids fromGelsemium elegansstems.Journal of Holistic Integrative Pharmacy2022, 3(3), 239–247.
(13)Pengfei Jin, Xinghua Yuan, Xiaomin Ma, Guijuan Zheng, Ru Wang, Na Sun, andGuangmin Yao*.Epoxymicranthols A−N, 5,9-epoxygrayanane diterpenoids as potent analgesics fromRhododendron micranthum. Chinese Journal of Chemistry2021,39(7),1997–2008.(IF: 5.560)
(14)Pengfei Jin, Guijuan Zheng, Xinghua Yuan, Xiaomin Ma, Yuanyuan Feng,Guangmin Yao*.Structurally diverse diterpenoids witheight carbon skeletons fromRhododendron micranthumand their antinociceptive effects.Bioorganic Chemistry2021,111,104870.(IF 5.307).
(15)Pengfei Jin, Guanqun Zhan, Guijuan Zheng, Junjun Liu, Xiang Peng, Lang Huang, Biao Gao, Xinghua Yuan,Guangmin Yao*. Gelstriamine A, a triamino monoterpene indole alkaloid with a caged 6/5/7/6/6/5 scaffold and analgesic alkaloids fromGelsemium elegansStems.Journal of Natural Products2021,84(4), 1326–1334.(IF: 4.803，Gelstriamine A被Natural Product Reports选为Hot off the press)
(16)Abdukriem Kadir#, Guijuan Zheng#, Xiaofeng Zheng#, Pengfei Jin, Biao Gao, Maitinuer Maiwulanjiang, Haji Akber Aisa*, andGuangmin Yao*.Structurally diverse diterpenoids from the roots ofSalvia desertabased on nine different skeletal types.Journal of Natural Products2021,84(5), 1442–1452. (IF: 4.803)
(17)Ru Wang#, Guijuan Zheng#, Ting Dang, Pengfei Jin, Jia Yao, Linjie Su,Guangmin Yao*, and Dongmei Qin*.Chemical constituents from the roots ofCichorium glandulosumBoiss. et Huet (Asteraceae).Biochemical Systematics and Ecology2021,96, 104261. (IF: 1.462)
(18)Guijuan Zheng#, Abdukriem Kadir#, Xiaofeng Zheng#, Pengfei Jin, Junjun Liu, Maitinuer Maiwulanjiang,Guangmin Yao*, and Haji Akber Aisa*.Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1ʹ-cyclohexane] motif fromSalviadeserta.Organic Chemistry Frontiers2020,7(20),3137–3145.(IF: 5.456,被Organic Chemistry Frontiers编辑部选为内封面文章)
(19)Junfei Zhou#, Zhili Zuo#, Junjun Liu, Hanqi Zhang, Guijuan Zheng, andGuangmin Yao*. Discovery of highly functionalized 5,6-seco-grayanane diterpenoids as potent competitive PTP1B inhibitors.Organic Chemistry Frontiers2020,7(6), 820−828. (IF: 5.456，被Organic Chemistry Frontiers编辑部选为外封面文章，并被选为2020Organic Chemistry FrontiersHot articles，被Natural Product Reports选为Hot off the press)
(20)Xiaofeng Zheng#, Abdukriem Kadir#, Guijuan Zheng#, Pengfei Jin, Dongmei Qin, Maitinuer Maiwulanjiang, Haji Akber Aisa*,Guangmin Yao*. Antiproliferative abietane quinone diterpenoids from the roots ofSalvia deserta.Bioorganic Chemistry2020,104,104261. (IF 5.307).
(21) Guijuan Zheng, Pengfei Jin, Lang Huang, Qihua Zhang, Lingkui Meng,Guangmin Yao*. Structurally diverse diterpenoids fromPieris japonicaas potent analgesics.Bioorganic Chemistry2020,99, 103794. (IF = 5.307).
(22) Hanqi Zhang, Xiang Peng, Xiaofeng Zheng, Shunyi Li, Yang Teng, Junjun Liu, Congming Zou,Guangmin Yao*. Lanostane triterpene glycosides from the flowers ofLyonia ovalifoliavar.hebecarpaand their antiproliferative activities.Bioorganic Chemistry2020,96, 103598. (IF: 5.307)
(23)Guijuan Zheng, Pengfei Jin, Lang Huang, Na Sun, Hanqi Zhang, Hao Zhang, Mingbo Yue, Lingkui Meng, andGuangmin Yao*. Grayanane diterpenoid glucosides as potent analgesics fromPieris japonica.Phytochemistry2020,171,112234.(IF: 4.004)
(24) Hanqi Zhang, Xiaofeng Zheng, Guijuan Zheng, Yang Teng, Junfei Zhou,Guangmin Yao*. Chemical constituents from the leaves ofLyonia ovalifoliavar.hebecarpa.Biochemical Systematics and Ecology2020,92, 104129. (IF: 1.462)
(25) Xiang Peng#, Hanqi Zhang#, Xinghua Yuan, Zibo Chen, Jinbo Gao, Yang Teng * andGuangmin Yao*. Grayanane diterpenoids from the leaves ofRhododendron dauricum.Biochemical Systematics and Ecology2020,89, 104009. (IF: 1.462)
(26) Qihua Zhang, Adam Smalley, Zhengdan Zhu, Zhijian Xu, Cheng Peng, Zhaoqiang Chen,Guangmin Yao*, Jiye Shi, Weiliang Zhu*. Computational study of the substituent effect of halogenated fused-ring heteroaromatics on halogen bonding.Journal of Molecular Modeling2020,26, 270. (IF: 2.172)
(27) Zong Jin*,Guangmin Yao*. Amaryllidaceae andSceletiumalkaloids.Natural Product Reports2019,36(10), 1462−1488.(IF: 15.111)
(28) Haofeng Zhou, Yindengzhi Guoruoluo, Yali Tuo, Junfei Zhou, Hanqi Zhang, Wei Wang, Ming Xiang, Haji Akber Aisa,Guangmin Yao*. Cassiabudanols A and B, immunostimulative diterpenoids with a cassiabudane carbon skeleton featuring a 3-oxa-tetracyclo[6.6.1.02,6.010,14]pentadecane scaffold from thecassia buds.Organic Letters2019, 21(2), 549−553. (IF: 6.072)
(29)Guijuan Zheng, Junfei Zhou, Lang Huang, Hao Zhang, Na Sun, Hanqi Zhang, Pengfei Jin, Mingbo Yue, Lingkui Meng,Guangmin Yao*. Antinociceptive Grayanane Diterpenoids from the Leaves ofPieris japonica.Journal of Natural Products2019,82(12), 3330−3339. (IF: 4.803)
(30)Na Sun, Guijuan Zheng, Meijun He, Yuanyuan Feng, Junjun Liu, Meicheng Wang, Hanqi Zhang, Junfei Zhou,Guangmin Yao*. Grayanane diterpenoids from the leaves ofRhododendron auriculatumand their analgesic activities.Journal of Natural Products2019,82(7), 1849−1860. (IF: 4.803)
(31)Na Sun, Yuanyuan Feng, Qihua Zhang, Junjun Liu, Haofeng Zhou, Hanqi Zhang, Guijuan Zheng, Junfei Zhou,Guangmin Yao*.Analgesic diterpenoids with diverse carbon skeletons from the leaves ofRhododendron auriculatum.Phytochemistry2019,168,112113.(IF: 4.004)
(32) Na Sun, Yue Qiu, Yan Zhu, Junjun Liu, Hanqi Zhang, Qihua Zhang, Mengke Zhang, Guijuan Zheng, Chun Zhang,Guangmin Yao*. Rhodomicranosides A−I, analgesic diterpene glucosides with diverse carbon skeletons fromRhododendron micranthum.Phytochemistry2019,158, 1−12. (IF: 4.004)曾被Web of Science评为领域中的高被引论文。
(33) Ting Dang, Guijuan Zheng, Qihua Zhang, Pengfei Jin, Hanqi Zhang, Lingjie Su, Dongmei Qin*,Guangmin Yao*. Sesquiterpenoids with diverse carbon skeletons from the roots ofCichorium glandulosumand their anti-inflammatory activities.Fitoterapia2019,136, 104170. (IF: 3.204)
(34) Junfei Zhou,Junjun Liu, Ting Dang, Haofeng Zhou, Hanqi Zhang, andGuangmin Yao*.Mollebenzylanols A and B, highly modifiedand functionalized diterpenoids with a 9-benzyl-8,10-dioxatricyclo[5.2.1.01,5]decane core fromRhododendron molle.Organic Letters2018, 20(7),2063−2066(IF: 6.072, mollebenzylanol A被Natural Product Reports选为Hot Off the Press；mollebenzylanols A and B被日本东京药科大学Hisanaka Ito全合成，Organic Letters2020, 22,7609−7612和Tetrahedron2021,83, 131958期刊上)
(35) Na Sun, Yan Zhu, Haofeng Zhou, Junfei Zhou, Hanqi Zhang, Mengke Zhang, Hong Zeng, andGuangmin Yao*. Grayanane diterpenoid glucosides from the leaves ofRhododendron micranthumand their bioactivities evaluation.Journal of Natural Products2018,81(12), 2673−2681. (IF: 4.803)
(36) Junfei Zhou, Tingting Liu, Hanqi Zhang, Guijuan Zheng, Yue Qiu, Mengyi Deng, Chun Zhang,andGuangmin Yao*.Anti-inflammatorygrayanane diterpenoids from the leaves ofRhododendronmolle.Journal of Natural Products2018,81(1), 151−161. (IF: 4.803)
(37) Yang Teng#, Hanqi Zhang#, Junfei Zhou, Guanqun Zhan,Guangmin Yao*. Hebecarposides A−K, antiproliferative lanostane-type triterpene glycosides from the leaves ofLyonia ovalifoliavar.hebecarpa.Phytochemistry2018,151, 32−41. (IF: 4.004)
(38) Yindengzhi Guoruoluo, Haofeng Zhou, Wei Wang, Junfei Zhou, Haji Akber Aisa*,Guangmin Yao*. Chemical constituents from the immature buds ofCinnamomum cassia(Lauraceae).Biochemical Systematics and Ecology2018,78, 102−105. (IF: 1.462)
(39) Junfei Zhou, Na Sun, Hanqi Zhang, Guijuan Zheng, Junjun Liu,andGuangmin Yao*. Rhodomollacetals A−C, PTP1B inhibitory diterpenoids with a 2,3:5,6-di-seco-grayanane skeleton from the leaves ofRhododendron molle.Organic Letters2017, 19(19),5352−5355. (IF:6.072,rhodomollacetal A被Natural Product Reports选为Hot Off the Press)
(40) Junfei Zhou, Guanqun Zhan, Hanqi Zhang, Qihua Zhang, Ying Li, Yongbo Xue,andGuangmin Yao*. Rhodomollanol A, a highly oxygenated diterpenoid with a 5/7/5/5 tetracyclic carbon skeleton from the leaves ofRhododendron molle.Organic Letters2017, 19(14),3935−3938. (IF: 6.072,rhodomollanol A已被浙江大学丁寒锋教授课题组成功全合成JACS2020,142(10), 4592-4597)
(41) Lei Zhou, Yali Tuo, Yi Hao, Xiaoman Guo, Wei Tang, Yongbo Xue, Junfen Zeng, Yu Zhou, Ming Xiang, Jianping Zuo,Guangmin Yao*, Yonghui Zhang*. Cinnamomols A and B, immunostimulative diterpenoids with a new carbon skeleton from the leaves ofCinnamomum cassia.Organic Letters2017, 19(11),3029−3032. (IF: 6.072,Cinnamomol A被Natural Product Reports选为Hot Off the Press)
(42)Yindengzhi Guoruoluo, Haofeng Zhou, Junfei Zhou, Haiqing Zhang, Haji Akber Aisa*,andGuangmin Yao*. Isolation and characterization of sesquiterpenoids fromcassia buds and their antimicrobial activities.Journal of Agricultural and Food Chemistry2017,65(28), 5614−5619. (IF: 5.895)
(43) Guanqun Zhan, Junjun Liu, Junfei Zhou, Bin Sun, Haji Akber Aisa,Guangmin Yao*. Amaryllidaceae alkaloids with new framework types fromZephyranthes candidaas potent acetylcholinesterase inhibitors.European Journal of Medicinal Chemistry2017,127, 771−780. (IF: 7.088)
(44)Guanqun Zhan, Junfei Zhou, Junjun Liu, Jinfeng Huang, Hanqi Zhang, Rong Liu,Guangmin Yao*. Acetylcholinesterase inhibitory alkaloids from the whole plants ofZephyranthes carinata.Journal of Natural Products2017,80(9), 2462−2472. (IF: 4.803，Zephycarinatines C和D最近已被日本京都大学的Hiroaki Ohno/Shinsuke Inuki课题组成功全合成Angew. Chem. Int. Ed.2020, 59, 21210–21215)
(45)滕杨#,张涵淇#,周俊飞,李永吉*,姚广民*.毛果南烛叶中的三萜皂苷化合物及其抗肿瘤活性.有机化学2017,36(9), 2416−2422. (IF: 1.652)
(46)朱焰,周俊飞,张颖,庞现红*,姚广民*.泰山产天目琼花枝叶化学成分研究.中草药2017,48(11), 2177−2181.
(47) Guanqun Zhan, Junfei Zhou, Tingting Liu, Guijuan Zheng, Haji Akber Aisa,Guangmin Yao*. Flavans with potential anti-inflammatory activities fromZephyranthes candida.Bioorganic & Medicinal Chemistry Letters2016,26(24), 5967−5970. (IF: 2.940)
(48) Guanqun Zhan, Junfei Zhou, Rong Liu, Tingting Liu, Guoli Guo, Jianping Wang, Ming Xiang, Yongbo Xue, Zengwei Luo, Yonghui Zhang,Guangmin Yao*. Galanthamine, plicamine, and secoplicamine alkaloids fromZephyranthes candidaand their anti-acetylcholinesterase and anti-inflammatory activities.Journal of Natural Products2016,79(4), 760−766. (IF: 4.803)
(49) Guanqun Zhan#, Xiaolan Qu#, Junjun Liu, Qingyi Tong, Junfei Zhou, Bing Sun,Guangmin Yao*. Zephycandidine A,the first naturally occurring imidazo[1,2-f]phenanthridine alkaloid fromZephyranthes candida, exhibits significant anti-tumor and anti-acetylcholinesterase activities.Scientific Reports2016,6, 33990.(IF: 4.996)
(50) Qi Ye#, Jue Jiang#, Guanqun Zhan#, Wanyao Yan, Liang Huang, Yufeng Hu, Hexiu Su, Qingyi Tong, Ming Yue, Hua Li,Guangmin Yao*, Yonghui Zhang*, Hudan Liu*.Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia.Scientific Reports2016,6,26510.(IF: 4.996)
(51) Yongji Lai, Hong Zeng, Meijun He, Huiqin Qian, Zhaodi Wu, Zengwei Luo, Yongbo Xue,Guangmin Yao*, Yonghui Zhang*. 6,8-Di-C-methyl-flavonoids with neuroprotective activities fromRhododendron fortune.Fitoterapia2016,112, 237−243. (IF: 3.204)
(52)Yongji Lai, Tingting Liu, Rongjian Sa, Xialan Wei, Yongbo Xue, Zhaodi Wu, Zengwei Luo, Ming Xiang, Yonghui Zhang*,Guangmin Yao*. Neolignans with a rare 2-oxaspiro[4.5]deca-6,9-dien-8-one motif from the stem bark ofCinnamomum subavenium.Journal of Natural Products2015,78(7), 1740−1744. (IF: 4.803)
(53) Mengke Zhang, Yangyang Xie, Guanqun Zhan, Liang Lei, Penghua Shu, Yongli Chen, Yongbo Xue, Zengwei Luo, Qian Wan,Guangmin Yao*, Yonghui Zhang*. Grayanane and leucothane diterpenoids from the leaves ofRhododendron micranthum.Phytochemistry2015,117, 107−115. (IF: 4.004)
(54) Qi Ye#,GuangminYao#, Mengke Zhang, Guoli Guo, Yufeng Hu, Jue Jiang, Ling Cheng, Hua Li, Guoliang Qing, Yonghui Zhang*, Hudan Liu*. A novelent-kaurane diterpenoid executes anti-tumor function in colorectal cancer cells by inhibiting Wnt/b-catenin signaling.Carcinogenesis2015,36(3), 318−326. (IF: 4.741)
(55) Guoli Guo#,Guangmin Yao#,Guanqun Zhan, Qi Ye, Jue Jiang, Yufeng Hu, Guoliang Qing, Yonghui Zhang*, Hudan Liu*.N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation.Toxicology and Applied Pharmacology2014,280(3), 475−483. (IF: 4.46)
(56) Junfen Zeng, Yongbo Xue, Penghua Shu, Huiqin Qian, Rongjian Sa, Ming Xiang, Xiao-Nian Li, Zengwei Luo,Guangmin Yao*, Yonghui Zhang*. Diterpenoids with immunosuppressive activities fromCinnamomum cassia.Journal of Natural Products2014,77(8), 1948−1954. (IF: 4.803)
(57) Mengke Zhang, Yan Zhu, Guanqun Zhan, Penghua Shu, Rongjian Sa, Liang Lei, Ming Xiang, Yongbo Xue, Zengwei Luo, Qian Wan,Guangmin Yao*, Yonghui Zhang*.Micrantone A, a new diterpenoid with an unprecedented carbon skeleton fromRhododendronmicranthum.Organic Letters2013,15(12), 3094−3097.(IF: 6.072)
(58) Heng Zheng, Qiong Chen, Mengke Zhang, Yongji Lai, Liang Lei, Penghua Shu, Yongbo Xue, Zengwei Luo, Jinwen Zhang, Yan Li,Guangmin Yao*,Yonghui Zhang*. Cytotoxicent-kaurane diterpenoids fromSalvia cavaleriei.Journal of Natural Products2013,76(12), 2253−2262. (IF: 4.803)
(59) Penghua Shu,Xialan Wei, Yongbo Xue, Weijie Li, Jinwen Zhang, Ming Xiang, Mengke Zhang, Zengwei Luo, Yan Li,Guangmin Yao*, Yonghui Zhang*. Wilsonols A–L, megastigmane sesquiterpenoids from the leaves ofCinnamomum wilsonii.Journal of Natural Products2013,76(7), 1303−1312. (IF: 4.803)
(60)Yongji Lai#, Yongbo Xue#, Mengke Zhang, Jinwen Zhang, Wei Tang, Junjun Liu, Liang Lei, Juming Yan, Zengwei Luo, Jianping Zuo, Yan Li,Guangmin Yao*, Yonghui Zhang*.Scapiformolactones A–I: germacrane sesquiterpenoids with an unusual Δ3-15,6-lactone moiety fromthe whole plants ofSalvia scapiformis.Phytochemistry2013,96, 378−388. (IF: 4.004)
(61) Xincai Hao#, Jinwen Zhang#, Guangxin Xia, Yongbo Xue, Zengwei Luo, Yanyan Si,Guangmin Yao*, Yonghui Zhang*.A new triterpenoid fromTeucrium viscidum.Molecules2013,18(1), 1262−1269.(IF: 4.927)
(62) Yongji Lai#, Shuiping Ding#, Huiqin Qian, Jinwen Zhang, Yongbo Xue, Zengwei Luo,Guangmin Yao*, Yonghui Zhang*.A new lignan glucoside from the whole plants ofSalvia scapiformis.Molecules2013,18(9), 11377−11383. (IF: 4.927)
(63) Xincai Hao#, Jinwen Zhang#, Guanqun Zhan, Yongbo Xue, Zengwei Luo,Guangmin Yao*, Yonghui Zhang*.Chemical constituents fromTeucrium viscidum.Biochemical Systematics and Ecology2013, 51, 78−82. (IF: 1.462)
(64)魏夏兰，舒朋华，刘婷婷，向明，张锦文，薛永波，罗增伟，姚广民*，张勇慧*.川桂皮中具有免疫调节活性的甾体和苯丙素类化学成分，有机化学，2013,33(6), 1273−1278. (IF: 1.652)
(65)曾红，钱慧琴，梁兆昌，杨亚军，褚洪标，张勇慧，姚广民*.云锦杜鹃化学成分研究，中草药，2013,44(22), 3123−3126.
(66) Zengwei Luo#, Fuqian Wang#, Jinwen Zhang, Xingyao Li, Mengke Zhang, Xincai Hao, Yongbo Xue, Yan Li, F. David Horgen,Guangmin Yao*, Yonghui Zhang*.Cytotoxic alkaloids from the whole plants ofZephyranthes candida.Journal of Natural Products2012,75(12), 2113−2120. (IF: 4.803)
(67) Jieru Guo, Jinwen Zhang, Penghua Shu, Lingmei Kong, Xincai Hao, Yongbo Xue, Zengwei Luo, Gao Li, Yan Li,Guangmin Yao*, Yonghui Zhang*.Two new diterpenoids from the buds ofWikstroemia chamaedaphne.Molecules2012,17(6), 6424−6433. (IF: 4.927)
在国内、外学术会议上作报告情况
(1)Guangmin Yao*.Novel Diterpenoids from the Ericaceae Medicinal Plants and Their Bioactivities.第七届可食和药用植物资源及功能成分国际学术研讨会（ISEPR2022），新疆乌鲁木齐，2022.11.19−2022.11.20，邀请报告。
(2)姚广民*.维吾尔药中新颖天然产物的发现及其生物活性研究.第二十届中药和天然药物学术研讨会，辽宁沈阳，2021.11.27−2021.11.28，邀请报告。
(3)姚广民*.维吾尔药中新颖天然产物的发现及其生物活性研究.北大-华科-石大药学周，新疆石河子大学，2021.10.23−2021.10.24，邀请报告。
(4)Guangmin Yao*.Novel Natural Products from the Roots ofSalvia desertand Their Biological Activities.XIVth International Symposium “Actual Problems of Chemistry, Biology and Technology of Natural Compounds(第十四届天然化合物化学国际会议)，乌兹别克斯坦，塔什干，2021.10.7−2021.10.8.邀请报告。
(5)姚广民*.维吾尔药中新颖天然产物的发现及其生物活性研究.第十三届全国天然有机化学学术研讨会，河南新乡，2021.9.18−2021.9.20.口头报告。
(6)姚广民*.新疆维药药效物质基础和作用机制研究.中国民族医药学会科研分会换届大会暨2021年学术年会，新疆石河子，2021.7.16−2021.7.19.邀请报告。
(7)姚广民*.杜鹃花科药用植物中新颖二萜类化合物的发现及其生物活性研究.天然有机（药物）化学高峰论坛（2019），甘肃兰州大学，2019.7.27−2019.7.30.口头报告。
(8)Guangmin Yao*. Immunomodulatory diterpenoids fromCinnamomum cassia.The 6th International Symposium on Edible Plant Resources and the Bioactive Ingredients，43。江苏南京，2018.10.14−2018.10.17。邀请报告。
(9)姚广民*.杜鹃花科药用植物的化学成分及生物活性研究.第十二届全国天然有机化学学术研讨会，101−101，昆明，2018.7.28−2018.7.31.邀请报告。
(10)Guangmin Yao*. Bioactive alkaloids fromZephyranthes candida. The 5thInternational Symposium on Edible Plant Resources and the Bioactive Ingredients，142−144，广东深圳，2016.11.4−2016.11.6。邀请报告。
(11)姚广民*.石蒜科药用植物葱莲的化学成分及生物活性研究.第十一届全国天然有机化学学术研讨会，150−150，上海，2016.9.25−2016.9.28.邀请报告。
(12)Guangmin Yao*. Bioactive alkaloids fromZephyranthes candida.第十届世界华人药物化学会议，54−55，台湾苗栗，2016.1.18−2016.1.20。邀请报告。
(13)Guangmin Yao*. Alkaloids fromZephyranthes candidaand their bioactivity evaluation. 2015杨凌国际农业科技论坛−天然产物：创新利用，113−114，陕西杨凌，2015.11.4−2015.11.7.邀请报告。
(14)Yao GM*.Chemical constituents and biological activities of twoZephyranthesspecies in China. The 28th International Symposium on the Chemistry of Natural Products and the 8th International Conference on Biodiversity，IUPAC，207−208，上海，2014.10.19−2014.10.24.邀请报告。
(15)Guangmin Yao*. Search for bioactive natural products using a bioassay based on inhibition of hypha formation inStreptomyces85E. The 3rd International Symposium on Edible Plant Resources and the Bioactive Ingredients，142−144，新疆乌鲁木齐，2012.7.28−2012.8.1。邀请报告。
(16)Guangmin Yao*. Search for bioactive natural products using a bioassay based on inhibition of hypha formation inStreptomyces85E. International Symposium on Exploration and Utilization of the Medicinal Plant Resources from Qinling Mountains，49−51，陕西宝鸡，2011.5.27−2011.5.29。邀请报告。
