阮汉利，医学博士，三级教授，博士生导师。现任我校同济新葡萄3522登录网页版中药与天然药物学系主任、天然药物化学与资源评价湖北省重点实验室副主任。兼任世界中医药学联合会中药化学专业委员会常务理事、湖北省药学会中药和天然药物专委会常务委员。主要从事天然药物活性成分的提取分离、结构鉴定和活性研究工作。主持多项国家和省部级科研项目。发表学术论文170余篇，其中100多篇为SCI收载。国家精品课程和国家级一流本科课程《天然药物化学》主讲教师之一。主讲本科生天然药物化学、天然药物化学实验、波谱解析及研究生结构解析等课程。主编、副主编和参编多部人民卫生出版社、医药科技出版社、高等教育出版社和中国中医药出版社的本科生国家统编教材。
学习经历：2001.9-2004.7:我校同济医学院新葡萄3522登录网页版，获得药理学博士学位；
1996.9-1999.7:同济医科大学新葡萄3522登录网页版，获药物化学专业硕士学位；
1985.9-1989.7:中国药科大学中药系，获理学学士学位；
2014.1-2014.6:德国马尔堡大学，访问学者
2007.7-10;2008.7-10:德国杜塞尔多夫大学，访问学者
2005.9-2006.9:德国图宾根大学及杜塞尔多夫大学，访问学者
工作经历：2014.11-今:我校同济新葡萄3522登录网页版教授，硕士、博士生导师，中药与天然药物学系主任；
2011.3-2014.11:我校同济新葡萄3522登录网页版教授，硕士、博士生导师，天然药物化学与中药学系副主任；天然药物化学课程群负责人；
2009.11-2011.2:我校同济新葡萄3522登录网页版教授，硕士、博士生导师；
2002.7-2009.10:我校同济新葡萄3522登录网页版副教授，硕士生导师；
1997.1-2002.6:我校同济医学院新葡萄3522登录网页版讲师；
1992.12-1996.12:同济医科大学新葡萄3522登录网页版助教
主要研究经历：
2021.01-2024.12：国家自然科学基金《三种蟹甲草属植物及其内生真菌抗AD次生代谢产物及机制》/63万（直接经费）/负责/项目编号22077041；
2018.01-2021.12：国家自然科学基金《基于多靶点机制的三种五味子属植物及其内生真菌抗AD活性成分研究》/60万（直接经费）/负责/项目编号31770380；
2016.01-2019.12：国家自然科学基金《三种核桃属植物PIN1靶向抗肿瘤萘醌类成分及作用机制》/77.4万/负责/项目编号21572073；
2013.01-2016.12：国家自然科学基金《金山五味子治疗阿尔茨海默症活性成分及机制》/80万/负责/课题编号31270394；
2021.01-2022.12：湖北省卫生健康委员会中医药科研项目《兴山五味子抗阿尔茨海默症物质基础研究》/5万/负责；
2013.01-2015.12：武汉市科技攻关项目《野核桃中新型凋亡诱导剂YHT-2和YHT-3抗肿瘤成药性评价》/30万/负责；
2011.1-2013.12：国家自然科学基金《换锦花抗AD活性成分及作用机制研究》/32万/负责/课题编号81072547；
2010.7-2013.6: 科技部国际合作项目《石蒜属植物中化学成分治疗阿尔茨海默症的临床前研究》/89万/负责/课题编号2010DFA32430；
2009.1-2011.12：国家自然科学基金《野核桃青果皮抗肿瘤活性成分及作用机制研究》/31万/课题编号30873361/负责；
2006.1-2007.12：湖北省自然科学基金项目野核桃果皮诱导肿瘤细胞Trail基因表达活性成分研究》/4万/课题编号：2006ABA125/负责；
2009.1-2009.12：中德合作PPP项目《生物信息学、分子生物学与化学相结合研究Aspergillus中次生代谢物的生物合成》
2007.1-2008.12：中德合作PPP项目《生物信息学、分子生物学与化学相结合研究真菌Aspergillus fisherianus中次生代谢物的生物合成》课题编号：留金出20063139
2004.1-2006.12：湖北省科技攻关项目《筒鞘蛇菰抗炎镇痛作用的研究与开发》负责；2004AA302B10
2002.1-2005.12：武汉市科技局青年科技晨光计划《湖北大戟抗肿瘤活性成分研究》负责；课题编号：20025001022
发表的主要论文（标*的为通讯作者）：
* Xiaogang Peng, Jinling Chang, Ying Gao, Fangfang Duan,Hanli Ruan*Thiocytochalasins A−D, four sulfur-containing cytochalasans from an endophytic fungusPhoma multirostrataXJ-2-1,Chinese Chemical Letters, 2022, 33(10): 4572-4576.
* Xiaogang Peng, Junjun Liu, Chunlun Qin, Qian Wu, Wanpeng Li, Fatemeh Mohammadipanah,Hanli Ruan* Ergochaeglobosins A-E, Unprecedented Heterodimers of Cytochalasan and Ergosterol fromChaeglobosin globosumP2-2-2,Chinese Journal of Chemistry,2022,40: 1909-1916.
* Ying Gao, Fangfang Duan, Jinling Chang, Xianggao Meng,Hanli Ruan* Resorcylic acid lactones from aPodosporasp. that induce apoptosis in activated T cells through MAPKs/AKT pathway,Bioorganic Chemistry, 2022, 118: 105482.
* Xiaogang Peng, Shuang Zhou, Junjun Liu, Ying Gao, Jinling Chang andHanli Ruan* (±)-Usphenethylones A–C, three pairs of heterodimeric polyketide enantiomers fromAspergillus ustus3.3904Organic & Biomolecular Chemistry, 2022, 20(3): 694-700.
* Ying Gao, Ruihua Mao, Ye Liu, Ming Zhou,Hanli Ruan* Cytochalasan Alkaloids as TRAIL Sensitizers from an Endophytic Fungus Chaetomium sp.Planta Medica, 10.1055/a-1728-4963. Advance online publication. https://doi.org/10.1055/a-1728-4963.
* An Jin, Fangfang Duan, Jinling Chang, Si Liu,Hanli Ruan* Chlorinated bisabolene sesquiterpenoids from the whole plant ofParasenecio rubescens,Fitoterapia, 2022, 156, 105093.
* Lin Liu,Hanli Ruan* An overview of natural austalides: Structure, bioactivity and synthesis,Phytochemistry Letters, 2022, 47, 81-92.
* Lin Liu, Fang-Fang Duan, Ying Gao, Xiao-Gang Peng, Jin-Ling Chang, Juan Chen, andHan-Li Ruan*Aspersteroids A–C, Three Rearranged Ergostane-type Steroids fromAspergillus ustusNRRL 275,Organic Letters, 2021,23 (24): 9620−9624.
* Fang-Fang Duan, Ying Gao, Jun-Jun Liu, Lin Liu, Xiao-Gang Peng, andHan-Li Ruan*Pseudeurglobosins A-F, Six Rearranged [11]-Chaetoglobosins with Immunosuppressive Activities from Pseudeurotium Bakeri P1-1-1Organic Chemistry Frontiers2021, 8(24), 7015-7024.
* Ming Zhou, Fangfang Duan, Ying Gao, Xiaogang Peng, Xianggao Meng, andHanli Ruan*Eremophilane Sesquiterpenoids from the Whole Plant ofParasenecio Albuswith Immunosuppressive Activity.Bioorganic Chemistry2021, 115: 105247.
* Fang-Fang Duan, Lin Liu, Ying Gao, Xiao-Gang Peng, Xiang-Gao Meng,Han-Li Ruan*[11]-Chaetoglobosins fromPseudeurotium bakeriInduce G2/M Cell Cycle Arrest and Apoptosis in Human Cancer CellsJournal of Natural Products2021, 84(7): 1904-1914.
* Ying Gao, Fang-Fang Duan, Lin Liu, Xiao-Gang Peng, Xiang-Gao Meng, andHan-Li Ruan*Hypothemycin-Type Resorcylic Acid Lactones with Immunosuppressive Activities from aPodosporasp.Journal of Natural Products2021, 84(2), 483-494.
* Lin, Yi, Jingjing Liang, Xiaogang Peng, andHanli Ruan*Phenolic Constituents from the Fresh Pericarps ofJuglans Sigillata.Natural Product Research2021, 35(8): 1242-1248.
* Lin, Yi, Xiaogang Peng, Juan Chen, Jia Zhou, andHanli Ruan*Triterpenoids from the Fresh Pericarps ofJuglans Hopeiensis.Natural Product Research2021, 35(2): 228-235.
* Xiao-Gang Peng, Junjun Liu, Ying Gao, Fang Cheng, Jin-Ling Chang, Juan Chen, Fang-Fang Duan andHan-Li Ruan*Pchaeglobolactone A, Spiropchaeglobosin A, and Pchaeglobosals A and B: Four Rearranged Cytochalasans fromChaetomium globosumP2-2-2Organic Letters2020, 22(24), 9665-9669.
* Juan Chen, Xiao-Gang Peng, Junjun Liu, Ying Gao, Ming Zhou, Jia Zhou, Jian Song, andHan-Li Ruan*Incarnolides A and B, Two Schinortriterpenoids with a Tricyclo[9.2.1.02,8]tetradecane-Bridged System fromSchisandra incarnata,Organic Letters2020, 22(3): 1071-1075.
* Jin-Ling Chang, Hong-Zhe Xu, Jia Zhou, Ming Zhou, Xuke Zhang, Yuanqiang Guo andHan-Li Ruan*Antimicrobial Furancarboxylic Acids from aPenicilliumsp.Journal of Natural Products2020, 83 (12): 3606-3613.
* Jia Zhou, Ying Gao, Jin-Ling Chang, Heng-Yi Yu, Juan Chen, Ming Zhou, Xiang-Gao Meng, andHan-Li Ruan*Resorcylic Acid Lactones from anIlyonectriasp.Journal of Natural Products2020, 83 (5): 1505-1514.
* Xiaogang Peng, Yangzhou He, Ying Gao, Fangfang, Duan, Juan Chen, andHan-Li Ruan*Cytochalasins from an endophytic fungusPhoma multirostrataXJ-2-1 with cell cycle arrest and TRAIL-resistance-overcoming activities,Bioorganic Chemistry,2020, 104, 104317.
* Xiaogang Peng, Fangfang Duan, Yangzhou He, Ying Gao, Juan Chen, Jinling Chang andHanli Ruan* Ergocytochalasin A, a polycyclic merocytochalasan from an endophytic fungusPhoma multirostrataXJ-2-1Organic & Biomolecular Chemistry, 2020, 18, 4056-4062
* Ming Zhou, Xiaogang Peng, Jia Zhou, Yie Liu, Xianggao Meng,Hanli Ruan* Triterpenoids from the stems and leaves ofSchisandra incarnata,Phytochemistry. 2020, 177, 112448.
* Ying Gao, Jia Zhou,Hanli Ruan* Trichothecenes from an Endophytic FungusAlternariasp. sb23,Planta Medica2020,86 (13/14): 976–982
* Xiaogang Peng, Yi Lin, Jingjing Liang, Ming Zhou, Jia Zhou,Hanli Ruan*Triterpenoids from the barks ofJuglans hopeiensis.Phytochemistry,2020. 170, 112201
* Yi Lin, Xiaogang Peng,Hanli Ruan*Diarylheptanoids from the fresh pericarps of Juglans hopeiensisFitoterapia2019, 136, 104165.
* Jing-Jing Liang, Jia Zhou, Jian Song, andHan-Li Ruan* Anthraquinone and Naphthoquinone Derivatives from the Pericarps ofJuglans sigillataChemistry of Natural Compounds, 2019, 55(3): 435-439.
* Aiqian Li#, Zhifeng Du#, Mei Liao, Yulin Feng,Hanli Ruan*and Hongliang Jiang* Discovery and Characterisation of Lycorine-Type Alkaloids inLycorisSpp. (Amaryllidaceae) Using UHPLC-QTOF-MS.Phytochemical Analysis, 2019, 30: 268–277.
* Wenming Wu &Hanli Ruan* Triterpenoids and lignans from the stems ofSchisandra glaucescensNatural Product Research, 2019, 33(3), 328–334.
* Ming Zhou, Jia Zhou, Junjun Liu, Jing-Jing Liang, Xiao-Gang Peng, Fang-Fang Duan, andHan-Li Ruan*. Parasubindoles A-G, Seven Eremophilanyl Indoles from the Whole Plant ofParasenecio albus.The Journal of Organic Chemistry, 2018, 83 (19), 12122–12128.
* Jian Song, Ming Zhou, Jia Zhou, Jing-Jing Liang, Xiao-Gang Peng, Junjun Liu, andHan-Li Ruan*. Schincalactones A and B, Two 5/5/6/11/3 Fused Schinortriterpenoids with a 13-Membered Carbon Ring System fromSchisandra incarnate.Organic Letters, 2018, 20 (8), 2499-2502.
* Ye Liu, Heng-Yi Yu, Hong-Zhe Xu, Jun-Jun Liu, Xiang-Gao Meng, Ming Zhou, andHan-Li Ruan*. Alkaloids with Immunosuppressive Activity from the Bark ofPausinystalia yohimbe.Journal of Natural Products, 2018, 81 (8), 1841–1849.
* Jingjing Liang, Xiaogang Peng, Jia Zhou, Ming Zhou &Hanli Ruan*Diarylheptanoids from the fresh pericarps ofJuglans sigillata,Natural Product Research, 2018, 32(20), 2457-2463.
* Jian Song, Ye Liu, Ming Zhou, Hui Cao, Xiao-Gang Peng, Jing-Jing Liang, Xiao-Ya Zhao, Ming Xiang,Han-Li Ruan*. Spiroschincarins A–E: Five Spirocyclic Nortriterpenoids from the Fruit ofSchisandra incarnata.Organic Letters, 2017, 19 (5), 1196–1199.
* Ye Liu, Heng-Yi Yu, Yan-Mei Wang, Tian Tian, Wen-Ming Wu, Ming Zhou, Xiang-Gao Meng,Han-Li Ruan*. Neuroprotective Lignans from the Fruits ofSchisandra bicolorvar.tuberculata.Journal of Natural Products, 2017, 80 (4), 1117–1124.
* Ye Liu, Tian Tian, Heng-Yi Yu, Ming Zhou,Han-Li Ruan*. Nortriterpenoids from the stems and leaves ofSchisandra viridis,Fitoterapia, 2017, 118: 38-41.
* An Jin, Wen-Ming Wu,Han-Li Ruan*.Sesquiterpenoids and monoterpenoid coumarins fromParasenecio rubescens,Rsc Advances, 2017, 7(9), 5167–5176.
* Ye Liu,Yan-Mei Wang, Wen-Ming Wu, Jian Song,Han-Li Ruan*. Triterpenoids and lignans from the fruit of Schisandra sphenanthera.Fitoterapia, 2017, 116:10–16.
* Ming Zhou, Ye Liu, Jian Song, Xiao-Gang Peng, Qi Cheng, Hui Cao, Ming Xiang, andHan-Li Ruan*,Schincalide A, a Schinortriterpenoid with a Tricyclo[5.2.1.01,6]decane-Bridged System from the Stems and Leaves of Schisandra incarnate.Organic Letters, 2016, 18 (18), 4558–4561.
* Wen-Ming Wu, Xu Chen, Ye Liu, Yan-Mei Wang, Tian Tian, Xiao-Ya Zhao, Juan Li,Han-Li Ruan*. Triterpenoids from the branch and leaf of Abies fargesii.Phytochemistry, 2016,130, 301–312.
* Heng-Yi Yu, Juan Li, Ye Liu, Wen-Ming Wu,Han-Li Ruan*. Triterpenoids from the fruit of Schisandra glaucescens.Fitoterapia, 2016, 113, 64–68.
* Wen-Ming Wu, Ye Liu, Xu Chen, An Jin, Ming Zhou, Tian Tian,Han-Li Ruan*, Diterpenoids from the branch and leaf of Abies fargesii,Fitoterapia, 2016, 110: 123-128.
* 毛瑞华，吴文明，方伟，阮汉利*.海洋真菌Aspergillus fumigatus次生代谢产物研究.天然产物研究与开发, 2016, 28: 1857-1863.
* 毛瑞华,钟志宏,吴文明,刘叶,阮汉利*.鄂西大蓟茎叶化学成分研究.中草药, 2016, 47(13): 2236-2240.
* Tian Tian, Ye Liu, Heng-Yi Yu, Yun-Yun Zhu, Xiao-Ya Zhao,Han-Li Ruan* Dibenzocyclooctadiene Lignans from the Fruits of Schisandra viridis,Chemistry of Natural Compounds, 2015,51 (6):1046-1048.
* An Jin, Wen-Ming Wu, Heng-Yi Yu, Ming Zhou, Ye Liu, Tian Tian, andHan-Li Ruan* Bisabolane-Type Sesquiterpenoids from the Whole Plant of Parasenecio rubescens,Journal of Natural Products, 2015,78 (8): 2057–2066.
* Yun-Yun Zhu, Xue Li, Heng-Yi Yu, Yu-Fang Xiong, Peng Zhang, Hui-Fang Pi,Han-Li Ruan*Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activitiesArchives of Pharmacal Research, 2015, 38 (5): 604-613.
* Yuan Gan, Yang Zhang, Aiqian Li, Chengwu Song, Chang Chen, Yong Xu,Hanli Ruan*, Hongliang*. Jiang, A Novel Four-step Approach for Systematic Identification of Naphthoquinones in Juglans cathayensis Dode using Various Scan Functions of Liquid Chromatography-Tandem Mass Spectrometry along with Data Mining Strategies.Phytochemical Analysis,2015, 26(6): 413–422.
Zhenzhong Chen, Ling Tong, Yuanli Feng, Jizhou Wu, Xiaoya Zhao,Hanli Ruan, Huifang Pi, Peng Zhang, Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus.Phytochemistry2015, 116, 329-336.
* Heng-Yi Yu, Zu-Yu Chen, Bin Sun, Junjun Liu, Fan-Yu Meng, Ye Liu, Tian Tian, An Jin, andHan-Li Ruan*, Lignans from the Fruit of Schisandra glaucescens with Antioxidant and Neuroprotective Properties,Journal of Natural Products, 2014, 77 (6): 1311–1320.
* An Jin, Xue Li, Yun-Yun Zhu, Heng-Yi Yu, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Four New Compounds from the Bulbs of Lycoris aurea with Neuroprotective Effects against CoCl2 and H2O2-induced SH-SY5Y Cell Injuries,Archives of Pharmacal Research2014, 37: 315-323.
* Wen-Ming Wu, Yun-Yun Zhu, Hao-ran Li, Heng-Yi Yu, Peng Zhang, Hui-Fang Pi,Han-Li Ruan*Two new alkaloids from the bulb of Lycoris sprengeri Journal of Asian Natural Products Research,2014, 16(2): 192-199.
Ke Jiao, Huo-Yun Li, Peng Zhang, Hui-Fang Pi,Han-Li Ruan, Ji-Zhou Wu Two new ent-kaurane diterpenoids from the aerial parts of Isodon excisoidesChinese Chemical Letters2014, 25(1): 131-133.
Ling Tong, Tu Chen, Zhenzhong Chen, Peng Zhang, Huifang Pi,Hanli Ruan, Jizhou. Wu, Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae.Journal of Ethnopharmacology2014, 155 (3), 1553-1560.
Juan Li, Hang Chang, Wenyu Zhao, Huifang Pi, Hanli Ruan, Peng. Zhang, New Alkaloids from Aconitum vaginatum.Helvetica Chimica Acta2014, 97 (5), 689-693.
* Heng-Yi Yu, Xiao-Qiong Zhang, Xue-Li, Fan-Bo Zeng,Han-Li Ruan*2-Methoxyjuglone Induces Apoptosis in HepG2 Human Hepatocellular Carcinoma Cells and Exhibits in Vivo Antitumor Activity in a H22 Mouse Hepatocellular Carcinoma Model,Journal of Natural Products2013, 76(5): 889−895.
* Juan Li, Jia-Xiang Sun, Heng-Yi Yu, Zu-Yu Chen, Xiao-Ya Zhao,Han-Li Ruan*Diarylheptanoids from the root bark ofJuglans cathayensis,Chinese Chemical Letters2013, 24: 521-523.
* Xue Li, Heng-Yi Yu, Zhuo-Yi Wang, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Neuroprotective Compounds from the Bulbs ofLycoris radiate,Fitoterapia2013, 88: 82-90.
Ke Jiao, Huo-Yun Li, Peng Zhang, Hui-Fang Pi,Han-Li Ruan, Ji-Zhou Wu Three new ursane-type triterpenoids from the aerial parts of Isodon excisoidesJournal of Asian Natural Products Research2013, 15(9): 962-968.
Kun Yang, Ling Tong, Chunxia Chen, Peng Zhang, Huifang Pi,Hanli Ruan, Jizhou. Wu, Therapeutic effects of extracts from Radix Toddaliae Asiaticae on collagen-induced arthritis in Balb/c mice.Journal of Ethnopharmacology2013, 146 (1), 355-362.
* Heng-Yi Yu, Cui Hao, Fan-Yu Meng, Xue Li, Zu-Yu Chen, Xi Liang,Han-Li Ruan*Neuroprotective Lignans from the Stems ofSchisandra glaucescensPlanta Medica2012,78: 1962-1966.
* Jia-Xiang Sun, Xiao-Ya Zhao, Xiao-Fang Fu, Heng-Yi Yu, Xue Li, Shu-Ming Li,Han-Li Ruan* Three new naphthalenyl glycosides from the root bark ofJuglans cathayensis,Chemical and Pharmaceutical Bulletin 2012, 60: 785-789.
Kathrin Mundt, Beate Wollinsky,Han-Li Ruan, Tianjiao Zhu and Shu-Ming Li, Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.Chembiochem2012, Nov 26; 13(17): 2583-2592 (This paper was selected as issue cover)
* Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Heng-Yi Yu, Shu-Ming Li, andHan-Li Ruan*. Schiglautone A, a New Tricyclic Triterpenoid with a Unique 6/7/9-Fused Skeleton from the Stems ofSchisandra glaucescens.Organic Letters,2011, 13 (6): 1502–1505.
* Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*. Triterpenoids from the Stems ofSchisandra glaucescens.Helvetica Chimica Acta,2011,94(10):1778-1785.
* Heng-Yi Yu, Xue Li, Fan-Yu Meng, Hui-Fang Pi, Peng Zhang,Han-Li Ruan*Naphthoquinones from the root barks ofJuglans cathayensisDode.Journal of Asian Natural Products Research,2011,13 (7): 581-587.
Li, Lujun; Zhang, Yue; Zhang, Peng; Pi, Huifang;Ruan, Hanli; Wu, Jizhou. Appraisal of anti-inflammatory and free radical scavenging activities of ethanol extract of Ilex ficoidea Hemsl and Ilex centrochinensis S.Y. Hu. Environmental Toxicology and Pharmacology 2011, 32(2), 122-127.
Zhang, Yue; Li, Lu-Jun; Zhang, Peng; Pi, Hui-Fang;Ruan, Han-Li; Wu, Ji-Zhou. Three New E-Secoursane Triterpenoid Saponins from the Leaves of Ilex dunniana. Helvetica Chimica Acta 2011, 94(12): 2207-2214.
Chen Chunxia, Zhang Peng, Pi Huifang,Ruan Hanli, Hu Zehua,Wu Jizhou. Extracts of Arisaema rhizomatum C.E.C. Fischer attenuate inflammatory response on collagen-induced arthritis in BALB/c mice.Journal of Ethnopharmacology. 2011, 133: 573-582.
Li, Lu-Jun; Zhang, Yue; Zhang, Peng; Pi, Hui-Fang;Ruan, Han-Li; Wu, Ji-Zhou. Flavans from the leaf of Ilex centrochinensis.Journal of Asian Natural Products Research 2011, 13(4): 367-372.
Li, Lu-Jun; Zhang, Yue; Zhang, Peng; Pi, Hui-Fang;Ruan, Han-Li; Wu, Ji-Zhou. Two new 5,8-quinoflavans from the leaf of Ilex centrochinensis. Journal of Asian Natural Products Research 2011, 13(4): 341-345.
* 陈超，胡钰，孙家祥，皮慧芳，张鹏，阮汉利*.野核桃叶化学成分研究.中草药, 2011，42(11), 2177-2180.
张悦,李陆军,张鹏,皮慧芳,阮汉利,吴继洲.冬青属两种植物的抗炎作用及自由基清除能力研究.我校学报(医学版), 2011, 40(1), 71-74.
* 张悦，阮汉利*，张勇慧，皮慧芳，吴继洲鄂西大蓟根的化学成分的研究天然产物研究与开发，2010, 22(1): 58-59
Han-Li Ruan, Edyta Stec and Shu-Ming Li. Production of diprenylated indole derivatives by tandem incubation of two recombinant dimethylallyltryptophan synthases Arch Microb 2009, 191: 791-795.
* PI Hui-fang, ZHANG Peng,RUAN Han-li*, ZHANG Yong-hui, SUN Han-dong, WU Ji-zhou A new triterpenoid from the leaves and stems ofFritillaria hupehensisJournal of Asian Natural Products Research 2009,11 (9): 779-782.
Nicola Steffan, Alexander Grundmann, Shamil Afiyatullov,Hanli Ruanand Shu-Ming Li FtmOx1, a non-heme Fe(II) and a-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus Org Biomol Chem. 2009, 7(19): 4082-7.
Zhang, Jiu-liang; Wang, Hui; Pi, Hui-fang;Ruan, Han-li; Zhang, Peng; Wu, Ji-zhou. Structural analysis and antitussive evaluation of five novel esters of verticinone and bile acids. Steroids 2009, 74(4-5), 424-434.
Zhou, Xue-Feng; Tang, Lan; Zhang, Peng; Zhao, Xiao-Ya; Pi, Hui-Fang; Zhang, Yong-Hui;Ruan, Han-Li; Liu, Yonghong; Wu, Ji-Zhou. The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var. hupehensis. Zeitschrift fuer Naturforschung, C: Journal of Biosciences 2009, 64(5/6), 369-372.
Zhou, Xue-Feng; Zhang, Peng; Pi, Hui-Fang; Zhang, Yong-Hui;Ruan, Han-Li; Wang, Hui; Wu, Ji-Zhou. Triterpenoids from the Roots of Actinidia chinensis. Chemistry & Biodiversity 2009, 6(8), 1202-1207.
徐仿周; 张鹏; 张勇慧; 阮汉利; 皮慧芳; 吴继洲湖北贝母总生物碱平喘作用及其机理的研究时珍国医国药2009; 20(6): 1335-1337.
徐仿周; 陈昶; 阮汉利; 张勇慧; 皮慧芳; 吴继洲湖北贝母有效部位提取工艺的研究时珍国医国药2009; 20(5): 1033-1034.
Han-Li Ruan,Wen-Bing Yin,Ji-Zhou Wu, Shu-Ming Li.Reinvestigation of a Cyclic Dipeptide N-Prenyltransferase Reveals Rearrangement of N-1 Prenylated Indole Derivatives.ChemBioChem2008, 9: 1044-1047.
* Hui Fang Pi Zhi Hong ZhongHan Li Ruan*Peng Zhang Yong Hui Zhang Ji Zhou Wu A new hopane triterpenoid from Saxiglossum angustissimum Chinese Chemical Letters 2008, 19: 835–836.
* LI Yi-xiu;RUAN Han-li*; ZHOU Xue-feng; ZHANG Yong-hui; PI Hui-fang and WU Ji-zhou Cytotoxic Diarylheptanoids from Pericarps ofJuglans CathayensisDode Chem.Res. Chinese Universities 2008, 24(4), 427 -429.
Zhang Yonghui, Yang, xiliang, Zhang Peng, Zhou, Xuefeng,Ruan Hanli, Pi Huifang, Wu Jizhou, Sun, Han-Dong. Cytotoxic alkaloids from the bulbs of Fritillaria hupehensis.Chemistry & Biodiversity. 2008, 5(2), 259-266.
Zhang Peng, Li Juan, Zhang Guoxin, Pi Huifang, Zhang Yonghui, Ruan Hanli, Wu Jizhou. Analysis of hupehenine in the total alkaloids from Fritillaria hupehensis by HPLC-ELSD. Journal of Huazhong University of Science and Technology, Medical Sciences. 2008, 28(1): 118-120.
* Ruan Han-Li*; Zhou Xue-Feng; Zhang Yong-Hui; Pi Hui-Fang; Wu Ji-Zhou; Sun Han-Dong Ferulic acid esters from Euphorbia hylonoma. Fitoterapia 2007, 78(1), 72-73.
* Pi, Hui Fang; Zhang, Peng; Zhu, Tian;Ruan, Han Li*; Zhang, Yong Hui; Sun, Han Dong; Wu, Ji Zhou. A new cycloartane triterpenoid from the leaves and stems of Fritillaria hupehensis. Chinese Chemical Letters 2007, 18(4), 418-420.
Yin, Wen-Bing;Ruan, Han-Li; Westrich, Lucia; Grundmann, Alexander; Li, Shu-Ming. CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: overproduction, purification and biochemical characterization. ChemBioChem 2007, 8(10), 1154-1161.
Zhang, Yonghui; Cai, Jinyan;Ruan, Hanli; Pi, Huifang; Wu, Jizhou. Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats. Journal of Ethnopharmacology 2007, 114(2), 141-145.
Zhou Xuefeng; Zhao Xiaoya; Tang Lan; Zhang Yonghui;Ruan Hanli;Pi Huifang; Qiu Jun; Wu Jizhou Immunomodulatory activity of the rhizomes of Impatiens pritzellii var. hupehensis on collagen-induced arthritis mice. Journal of Ethnopharmacology 2007, 109(3), 505-509.
Zhang, Yong-Hui; Yang, Xi-Liang; Zhou, Xue-Feng;Ruan, Han-Li; Pi, Hui-Fang; Wu, Ji-Zhou; Sun, Han-Dong. Alkaloids from Fritillaria hupehensis. Chinese Journal of Chemistry (2007), 25(11), 1728-1731.
Xu, Fang-zhou; Chen, Chang; Zhang, Yong-hui;Ruan, Han-li; Pi, Hui-fang; Zhang, Pong; Wu, Ji-zhou. Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent. Acta Pharmacologica Sinica (2007), 28(10), 1591-1596.
Zhang, Yong Hui; Yang, Xi Liang; Zhou, Xue Feng;Ruan, Han Li;Pi, Hui Fang; Wu, Ji Zhou; Sun, Han Dong; Fujita, Tetsuro. A new veratramine alkaloid from the bulbs of Fritillaria hupehensis. Chinese Chemical Letters 2007, 18(2), 175-177.
Zhou, Xue-Feng; Tang, Lan; Zhang, Yong-Hui; Pi, Hui-Fang;Ruan, Han-Li; Wu, Ji-Zhou. Nitrogenous compounds from Impatiens pritzellii var. hupehensis (Balsaminaceae). Biochemical Systematics and Ecology 2007, 35(5), 308-310.
Xu Fang-Zhou; Chen Chang; Zhang Yong-Hui;Ruan Han-Li; Pi Hui-Fang; Zhang Pong; Wu Ji-Zhou. Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent. Acta pharmacologica Sinica 2007, 28(10), 1591-6.
Zhou X-F; Zhao X-Y; Tang L;Ruan H-L; Zhang Y-H; Pi H-F; Xiao W-L; Sun H-D; Wu J-Z Three new triterpenoid saponins from the rhizomes of Impatiens pritzellii var. hupehensis. Journal of Asian Natural Products Research 2007, 9(4), 379-385.
Hui-Fang Pi,Han-Li Ruan, Yong-Hui Zhang, Ji-Zhou Wu.Two new steroidal alkaloids from bulbs of Fritillaria lichuanensisJournal of Asian Natural Products Research 2006,8(3):253-257.
Hui-Fang Pi,Han-Li Ruan, Yong-Hui Zhang, Lei-Ming Niu, Ji-Zhou Wu. Steroidal alkaloids from bulbs ofFritillaria lichuanensisJournal of Asian Natural Products Research 2006, 8(1-2): 133-136.
Zhang Yong-hui,Ruan Han-li. A new steroidal alkaloid from bulbs of Fritillaria Hupehensis Hsiao et K.C. Hsia.Chemical Research of Chinese Universities, 2004,20（6）：804-806.
Zhang Yong-hui,Ruan Han-li. Structural elucidation of fritillahupehin from bulbs of Fritillaria Hupehensis Hsiao et K. C. Hsia.Journal of Asian Natural Products Research 2004; 6(1): 29-34.
Ruan Han-li, Zhang Yong-hui,Wu Ji-zhou. Two new diterpenoid dimers, fritillebinide D and E, from bulbs offritillaria ebeiensisJournal of Asian Natural Products Research2002;4(4): 309-314.
Ruan Han-li, Zhang Yong-hui,Wu Ji-zhou.Structure of a novel diterpenoid ester, fritillahupehin, from bulbs offritillaria hupehensisHsiaoetK. C. HsiaFitoterapia 2002: 73(4): 288-291.
Wu Ji-zhou,Ruan Han-li, Yao Nian-huan.Structures of Two Diterpenoid Dimers from Bulbs ofFritillaria ebeiensis.Journal of Asian Natural Products Research2000, 2 (3): 161-167.
Wu Ji-zhou, Wen Yu-ping,Ruan Han-li. Structural Elucidation of TwoEnt-kauran Dimers from Bulbs ofFritillariaebeiensisvar.purpurea. Journal of Asian Natural Products Research 2000, 2(3): 213-218.
Wu Ji-zhou,Ruan Han-li, Zeng Chun-lan. Structures of Two New Diterpenoid Dimers from Bulbs of Fritillaria ebeiensis. J Asia Nat Prod Reseach 1999; 1: 251-257.
专利申请：
1. 2004100607538湖北贝母中提取的单体生物碱在制备镇咳祛痰平喘药物中的应用
2. 2004100607542浙贝乙素及其衍生物在制备镇咳祛痰平喘药物中的应用
3. 2004100607523浙贝乙素及其衍生物在制备抗肿瘤药物中的应用
4. 2006100190270浙贝乙素和胆汁酸的衍生物及药物组合物
5. 2008100487229浙贝乙素胆汁酸酯及其制备方法和应用
6. 2009100611697用于预防或治疗痴呆症的组合物
7. KR 2010104064 Lycoris aurea extracts for preventing and treating dementia, Repub. Korean
8. 2010105959577两个萘醌类化合物在制备抗肿瘤类药物中的应用
9. WO 2012/026641 A1 Composition for preventing or treating dementia
10. 2012104169575 一种木脂素类化合物及其制备方法和应用
11. 2012104179007 一种木脂素类化合物及其在防治阿尔茨海默症中的应用
12. 2013100756654 具有神经保护作用的石蒜科生物碱类化合物
13. 2013100764684 具有神经保护作用的石蒜伦碱类化合物
14. 2013100764665 一个具有神经保护作用的石蒜碱类化合物
15. 2013106738541 一种用于预防和治疗阿尔茨海默症的药物及其制备方法
副主编和参编教材：
主编《天然药物化学》(医药科技出版社，2021年出版)；（全国普通高等医学院校“十四五”药学类专业规划教材）
主编《天然药物化学》(医药科技出版社，2016年出版)；（全国药学类专业“十三五”规划教材）
副主编《天然药物化学题库》(人民卫生出版社，2019年)；
参编《波谱解析》第二版(人民卫生出版社，2016年出版)；
副主编《天然药物化学》(医药科技出版社，2015年8月出版)；
参编《波谱解析》(中医药出版社，2014年出版)；
副主编《天然药物化学》(高等教育出版社，2010年5月出版)；
参编《波谱解析》(人民卫生出版社，2011年7月出版)；
参编《天然药物化学》(医药科技出版社，2008年8月出版)；
参编《天然药物化学图表解》(人民卫生出版社，2008年10月出版)；
参编《天然药物化学学习指导》(人卫出版社，2005年2月出版)；
参编《天然药物化学习题集》第二版(人卫出版社，2007年8月出版)；
参编《药物计量学》(医药科技出版社，2006年4月出版)。
专著：
副主编《华中地区常见常用药用植物图鉴》(科学出版社，2021；ISBN 978-7-03-067197-4)。
参编《鄂西常用药用植物图鉴》(湖北科学技术出版社，2020；ISBN 978-7-5706-1178-2)。
参加会议：
2021.10.8-11，世界中医药学会联合会中药化学专业委员会第九届学术年会、2021年10月8-11日，兰州，中国
2016. 9. 25-28,中国化学会第十一届全国天然有机化学学术会议，上海，中国
2014. 11. 21-23,中国化学会第十届全国天然有机化学学术会议，广州，中国
2014. 10. 20-24, 28th International Symposium on the Chemistry of Natural Products and the 8th International Conference on Biodiversity (ISCNP28 & ICOB8), Shanghai, China
2012. 8. 23-26,韩国首尔the 7th KSP-JSP-CCTCNM Joint Symposium on Pharmacognosy (第7届中日韩三国生药学联合学术研讨会)交流论文Diarylheptanoids from the root bark of Juglans cathayensis Dode
2011. 8. 10-12,昆明野核桃根皮化学成分研究，第十届全国药用植物及植物药学术研讨会PP159
Zongfang Wang, Hengyi Yu, Hanli Ruan*, Huifang Pi, Peng Zhang, Jizhou Wu. Five new compounds fromJuglans cathayensisthe 5th JSP-CCTCNM-KSP Joint Symposium. September 24th 2010.Tokushima-Japan.
Nicola Steffan, Inge Unsöld, Alexander Grundmann, Wen-Bing Yin, Anika Kremer, Hanli Ruan, Shu-Ming Li.Evolution of aromatic prenyltransferases in the biosynthesis of indole derivatives.7thColloquium of SPP 1152: Evolution of Metabolic Diversity, 3.04.2008,Halle (Saale), Germany.
Wen-Bing Yin, Han-Li Ruan, Lucia Westrich, Alexander Grundmann and Shu-Ming Li. CdpNPT, an N-prenyltransferase fromAspergillus fumigatus: Overproduction, purification and biochemical characterization.„Tag des Wissenschaftlichen Nachwuchses“, 22.06.2007, HHU Düsseldorf.
Wen-Bing Yin, Han-Li Ruan, Lucia Westrich, Alexander Grundmann and Shu-Ming Li.CdpNPT, a tryptophan-containing cyclic dipeptide N1-prenyltransferase fromAspergillus fumigatus.VAAM International Workshop: Biology of Bacteria Producing Natural Products,4-6.10.2007, European Academy Otzenhausen, Germany.
2007. 12. 4-5:江西南昌交流论文A new Diarylheptanoid from Juglans Cathayensis Dode第九届全国中药和天然药物学术研讨会
2000.3.17-19：中国昆明交流论文Diterpenoids from the bulbs of fritillaria ebeiensis var. purpurea。UNESCO Regional Symposium on Chemistry of Medicinal Plants.
1997. 10.28-31：日本京都交流论文Structures of Six Novel Diterpenoids from Fritillaria ebeiensis. International Symposium on Natural Medicines, Kyoto, Japan, Oct. 28-30, 1997
获奖情况：
2003年被评为我校“三育人积极分子”。2001-2002学年获我校教学质量优秀二等奖。1999、2000、2001、2015、2017、2018、2019、2021年考核优秀。2005年湖北省自然科学三等奖（排名第二）。2005年我校优秀博士学位论文。2009和2010年指导本科生论文获湖北省大学本科生毕业论文一等奖。
硕士/博士研究生招生方向：药物化学（含天然药物化学）、中药与天然药物学
联系方式：我校同济医学院新葡萄3522登录网页版阮汉利；邮编430030
Email:ruanhl@hust.edu.cn;ruanhl@mails.tjmu.edu.cn
