姜宏梁
1976年11月，男，博士，我校教授、博士生导师，武汉市首批“黄鹤英才计划”入选者，中国生物分析协会指导委员会委员，世界中联中药鉴定委员会理事，武汉市药学会药物分析专业委员会副主任委员。为人卫版药物分析教材第八版编委，Acta Pharm Sin B和药学学报青年编委，Biomedical Chromatography编委。主持国家自然科学基金、湖北省卫生厅、武汉市人才计划及多项企业合作项目等。曾主持和参与超过100项生物等效性或药代动力学研究项目。为国家科学技术奖励评审、“重大新药创制”科技重大专项、国家自然科学基金、教育部博士点基金评审专家，Journal of Chromatography A, Journal of Chromatography B及Talanta等学术期刊特邀审稿人。参与国家食品药品监督总局2016年组织的以《药动学参数为终点评价指标的化学药物仿制药人体生物等效性研究技术指导原则》和《仿制药质量和疗效一致性评价临床有效性试验一般考虑的意见》的讨论与制定。目前，已发表SCI收录论文50多篇。
主要研究兴趣与方向：药物分析和代谢、中药药代动力学及代谢组学。
教育背景
2001/08-2005/07 美国亚利桑那大学 药学 博士
1998/09-2001/07 北京协和医学院 生药学 硕士
1994/09-1998/07 沈阳药科大学 中药制药专业 学士
工作经历
2011/04-现在 我校 药物分析与代谢 教授、博导
2010/11-2011/04美国Covance Inc.公司 药物分析与药代动力学资深研究员
2006/12-2010/11美国Covance Inc.公司 药物分析与药代动力学研究员
2005/08-2006/11美国西北太平洋国家实验室生物分析 博士后
部分主持和参与科研项目
1.基于LC-MS/MS特征轮廓谱分析方法的姜黄中强抗肿瘤活性微量姜黄素类化合物的快速发现，项目批准号：31270392，国家自然科学基金，面上项目，2013.01-2016.12，项目主持人。
2.姜黄中姜黄素类化合物的系统分离与抗肿瘤活性研究，湖北省中医药中西医结合科研项目-湖北省卫生厅项目，2012.01-2014.12，项目主持人。
3.药物分析和药代动力学研究技术服务平台建设，武汉市首批“黄鹤英才计划”资助， 2012.03-2014.12，项目主持人。
4.拟靶向代谢组学策略筛选动脉粥样硬化LysoPL标记物群及其在泽泻三萜药效研究中的应用，项目批准号：81603068，国家自然科学基金，青年基金，2017.01-2019.12，项目参与人。
5.基于DNA分子标记-谱效关系的药用紫草品质资源评价研究，项目批准号：U1603104，国家自然科学基金，联合基金项目，2017.01-2019.12，项目主持人。
6.基于靶向脂质组学和蛋白组学的姜黄降脂作用机制研究，项目批准号：81874309，国家自然科学基金，面上项目，2019.01-2022.12，项目主持人。
发表论文
1.Meiling Huang, Zhongzhe Cheng, Lu Wang, Yulin Feng, Jiangeng Huang, Zhifeng Du, Hongliang Jiang*, A targeted strategy to identify untargeted metabolites from in vitro to in vivo: Rapid and sensitive metabolites profiling of licorice in rats using ultra-high performance liqud chromatography coupled with triple quadrupole-linear ion trap mass spectrometry, Journal of Chromatography B, 2018, 1092:40-50.
2.Yingfei Yan, Zhifeng Du, Hongliang Jiang*, HRMS for the quantification of xenobiotics in biological samples, Bioanalysis, 2017, 9(24), 1939-1941.
3.Sen Li, Shuna Jin, Chengwu Song, Shuailong Jia, Yang Zhang, Yulin Feng, Zhifeng Du*, Hongliang Jiang*, The strategy for establishemeng of the multiple reaction monitoring based characteristic chemical profile of triterpenes in Alismatis rhizoma using two combined tandem mass spectrometers, Journal of Chromatography A, 2017, 1524, 121-134.
4. Shuailong Jia, Zhifeng Du, Chengwu Song, Shuna Jin, Yang Zhang, Yulin Feng, Chaomei Xiong, Hongliang Jiang*, Identification and characterization of curcuminoids in turmeric using ultra-high performance liquid chromagraphy-quadrupole time of flight tandem mass spectrometry, Jounal of Chromatography A, 2017, 1521, 110-122.
5. Liang Liu, Xing Zhou, Tingting Wu, Hongliang Jiang, Sitao Yang, Yang Zhang, Dose optimisation of voriconazole with therapeutic drug monitoring in children: a single-centre experience in China, International Journal of Antimicrobial Agents, 2017, 49, 483-487.
6.Guiying Chen#,Chengwu Song#, ShunaJin, Sen Li, Yang Zhang, Rongzeng Huang, Yulin Feng, Yong Xu, Yi Xiang,Hongliang Jiang*, An integrated strategy for establishment of metabolite profile of endogenous lysoglycerophospholipids by two LC-MS/MS platforms, Talanta, 2017, 162, 530-539.
7. ShunaJin#, Chengwu Song#, ShuailongJia, Sen Li, Yang Zhang, Cheng Chen, Yulin Feng, Yong Xu, ChaomeiXiong, Yi Xiang, Hongliang Jiang*, An integrated strategy for establishment of curcuminoid profile in turmeric using two LC-MS/MS platforms, Journal of Pharmaceutical and Biomedical Analysis, 2017, 132, 93-102.
8. Zhongzhe Cheng, Xing Zhou, Bingying Hu, Wenyi Li, Guiying Chen, Yang Zhang, Jingkui Tian, Lin Zhang, Ming Li*, Hongliang Jiang*, Tissue distribution of capilliposide B, capilliposide C and their bioactive metabolite in mice using liquid chromatography-tandem mass spectrometry, Biomedical Chromatography, 2016, doi:10.1002/bmc.3895.
9.Chang Chen, Ariane Wohlfarth, Hui Xu, Dan Su, Xin Wang, Hongliang Jiang, Yulin Feng, Mingshe Zhu, Untargeted screening of unknown xenobiotics and potential toxins in plasma of poisoned patients using high-resolution mass spectrometry: Generation of xenobiotic fingerprint using background subtraction, AnalyticaChimicaActa, 2016, 944, 37-43.
10.Chang Chen, Bingying Hu, Tongzhi Wu, Yang Zhang, Yong Xu, Yulin Feng, Hongliang Jiang*, Bile acid profiles in diabetic (db/db) mice and their wild type littermates, Journal of Pharmaceutical and Biomedical Analysis, 2016, 131, 473-481.
11.Zhongzhe Cheng, Xing Zhou, Wenyi Li, Bingying Hu, Yang Zhang, Yong Xu, Lin Zhang*, Hongliang Jiang*, Optimization of solid-phase extraction and liquid chromatography-tandem mass spectrometry for simultaneous determination of capilliposide B and its active metabolite in rat urine and feces: overcoming nonspecific binding, Journal of Pharmaceutical and Biomedical Analysis, 2016, 131, 6-12.
12.Guiying Chen, Zhongzhe Cheng, Kerong Zhang, Hongliang Jiang*, Mingshe Zhu*, An integrated approach for profiling oxidative metabolites and glutathione adducts using liquid chromatography coupled with ultraviolet detection and triple quadrupole-linear ion trap mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2016, 129, 482-491.
13.Xin Zhou, Chang Chen, Fangrong Zhang, Yang Zhang, Yulin Feng, Hui Ouyang, Yong Xu, Hongliang Jiang*, Metabolism and bioactivation of the tricyclic antidepressant amitriptyline in human liver microsomes and human urine, Bioanalysis, 2016, 8(13), 1365-1381.
14.Xin Zhou, Fangrong Zhang, Chang Chen, ZitaoGuo, Jia Liu, Jinghua Yu, Yong Xu, DafangZhong*, Hongliang Jiang*, Impact of curcumin on the pharmacokinetics of rosuvastatin in rats and dogs based on the conjugated metabolites, Xenobiotica, 2016, 47(3),267-275.
15.Chengwu Song, Qingsong Yu, Xiaohua Li, ShunaJin, Sen Li, Yang Zhang, ShuailongJia, Cheng Chen, Yi Xiang, Hongliang Jiang*, The hypolipidemic effect mice and its composition characterized by UPLC-QTOF-MS/MS, Journal of Food Science, 2016, 81(5), 1313-1319.
16.Guangjie Yang, Fangrong Zhang, Linfang Deng, Chang Chen, Zhongzhe Cheng, Jiangeng Huang, Jiangyun Liu*, Hongliang Jiang*, Development and validation of an LC-MS/MS method for simultaneous quantification of levodopa and MD01 in rat plasma and its application to a pharmacokinetic study of mucunapruriens extract, Biomedical Chromatography, 2016, 30(9), 1506-1514.
17.Zhongzhe Cheng, Meilin Huang, Guiying Chen, Guangjie Yang, Xin Zhou, Chang Chen, Yang Zhang, Yong Xu, Yulin Feng, Lin Zhang*, Hongliang Jiang*, Cell-based assays in combination with ultra-high performance liquid chromatography-quadrupole time of flight tandem mass spectrometry for screening bioactive Capilliposide C metabolites generated by rat intestinal microflora, Journal of Pharmaceutical and Biomedical Analysis, 2016, 119, 130-138.
18.Sen Li, Chengwu Song, Chang Chen, Yang Zhang, Yi Xiang, Yong Xu, Yulin Feng, Qian Wan*, Hongliang Jiang*, The metabolic change of serum lysophosphatidylcholines involved in the lipid lowering effect of triterpenes from Alismatisrhizoma on high-fat diet induced hyperlipidemia mice, Journal of Ethnopharmacology, 2016, 177, 10-18.
19.Mei Liao, Aiqian Li, Chang Chen, Hui Ouyang, Yang Zhang, Yong Xu, Yulin Feng, Hongliang Jiang*, Systematic identification of shikonins and shikonofurans in medicinal Zicao species using ultra-high performance liquid chromatography quadrupole time of flight tandem mass spectrometry combined with a data mining strategy, Journal of Chromatography A, 2015,1425,158-172.
20.Yuan Gan#, Yang Zhang#, Aiqian Li, Chengwu Song, Chang Chen, Yong Xu,HanliRuan*,Hongliang Jiang*,A novel four-step approach for systematic identification of naphthoquinones in JuglanscathayensisDode using various scan functions of liquid chromatography-tandem mass spectrometry along with data mining strategies, Phytochemical Analysis, 2015, 26(6):413-422.
21.Zhongzhe Cheng#, Lian Ding#, Yang Zhang, Guiying Chen, Chang Chen, Yi-Qiang Cheng, Hongliang Jiang*, Determination of Thailandepsin B in Rat Plasma with a LC-MS/MS Method, Bioanalysis, 2015, 7(1): 39-52.
22.Zhifeng Li, Yawei Wang, Hui Ouyang, Yu Lu, Yan Qiu,Yulin Feng*, HongliangJiang*, Xin Zhou, Shilin Yang, A novel dereplication strategy for the identification of two new trace compounds in the extract of Gastrodiaelata using UHPLC/Q-TOF-MS/MS, Journal of Chromatography B, 2015, 988: 45-52.
23.Hui Ouyang, YichengGuo, Mingzhen He, Jinlian Zhang, Xiaofang Huang, Xin Zhou, HongliangJiang, Yulin Feng*, Shilin Yang, A Rapid and Sensitive LC-MS/MS Method for the Determination of PulsatillaSaponin D in Rat Plasma and its Application in a Rat Pharmacokinetic and Bioavailability Study, Biomedical Chromatography, 2015, 29(3): 373-378.
24.Cai Huang#, Qiongming Xu#, Chang Chen, Chengwu Song, Yong Xu, Yi Xiang, Yulin Feng, Hui Ouyang, Yang Zhang, HongliangJiang*, The Rapid Discovery and Identification of Physalins in the Calyx of PhysalisAlkekengiL.Var.franchetii (Mast.) Makino Using Ultra-high Performance Liquid Chromatography-quadrupole Time of Flight Tandem Mass Spectrometry together with a Novel Three-step Data Mining Strategy. Journal of Chromatography A, 2014, 1361: 139-152.
25.Shuna Jin, ChengwuSong, Sen Li, Yang Zhang, Chang Chen, Xin Zhou, Yong Xu, YulinFeng, ZhipingZhang*, HongliangJiang*, Preventative Effects of Turmeric on the High-fat Diet-induced Hyperlipidaemia in Mice Associated with a Targeted MetabolomicApproach for the Analysis of Serum LysophosphatidylcholineUsing LC-MS/MS. Journal of Functional Foods, 2014, 11: 130-141.
26.Zhongzhe Cheng, Lin Zhang, Yang Zhang, GuiyingChen, HongliangJiang*, Simultaneous Determination of Capilliposide B and CapilliposideC in Rat Plasma by LC-MS/MS and its Application to a PK Study, Bioanalysis, 2014, 6(7): 935-945.
27.Ning Li, XuefengZhou, JiyanYuan, GuiyingChen, HongliangJiang, Wen Zhang*, Ceftriaxone and Acute Renal Failure in Children, Pediatrics, 2014, 133(4): 917-922.
28.YangZhang, HuachuanCao, HongliangJiang*. Supported Liquid Extraction versus Liquid-liquid Extraction for Sample Preparation in LC-MS/MS-based Bioanalysis, Bioanalysis, 2013, 5(3): 285-288.
29.Daniel Tang*, DafangZhong, Kelly Dong, Pei Hu, HuichenLiu, HongliangJiang，Alicia Du. China Bioanalysis Forum, Bioanalysis, 2013, 5(6): 641-643.
30.Pei-pei Zhang, Sha-shaGao, Tian-tian Zhang, Xiao-gang Wang, Guo-liangQing, Hong-liangJiang, Jia-chunChen, Hong-quanDuan, Jin-boFang*, Two New Compounds from SchisandraGlaucescens, Journal of Asian Natural Products Research, 2013, 15(5): 466-472.
31.Hongliang Jiang#*, HuachuanCao#*, Yang Zhang, Douglas M. Fast, Systematic Evaluation of Supported Liquid Extraction in Reducing Matrix Effect and Improving Extraction Efficiency in LC-MS/MS based Bioanalysis for 10 Model Pharmaceutical Compounds, Journal of Chromatography B, 2012, 891-892: 71-80.
32.Yang Zhang, HongliangJiang, Paul Hutson*, Stability of Acetyl-I-carnitine in 5% Dextrose Using a High-performance Liquid Chromatography-mass Spectrometry Times 2 Method, International Journal of Pharmaceutical Compounding, 2012, 16(2): 170-173.
33.Yi Xiang, LipingZhou, ZhenyuQian, KelongPeng, DongyanLi, XiaomeiChen, HongliangJiang, HengZheng*, Determination of Cyclobenzaprine in Human Plasma by Liquid Chromatography-electrospray Ionization Tandem Mass Spectrometry and its Application in a Pharmacokinetic Study, Biomedical Chromatography, 2012, 26(9): 1083-1088.
34.YifanShi*,HongliangJiang, Assay Dynamic Range for DBS: battles on two Fronts, Bioanalysis, 2011, 3(20): 2259-2262.
35.Hongliang Jiang H*, YurongWang, Manjunath S. Shet, Yang Zhang, Duane Zenke, Douglas M. Fast, Development and Validation of a Sensitive LC-MS/MS Method for the Simultaneous Determination of Naloxone and its Metabolites in Mouse Plasma, Journal of Chromatography B, 2011, 879(25): 2663-2668.
36.Hongliang Jiang H*, Yang Zhang, Matt Ida, Amber LaFayette, Douglas M. Fast, Determination of Carboplatin in Human Plasma Using HybridSPE-precipitation along with Liquid Chromatography-tandem Mass Spectrometry, Journal of Chromatography B, 2011，879 (22): 2162-2170.
37.Xiaorong Liang#*, HongliangJiang#, Xi Chen,Human DBS Sampling with LC-MS/MS for Enantioselective determination of Metoprolol and its Metabolite O-Desmethyl Metoprolol, Bioanalysis, 2010, 2(8): 1437-1448.
38.Hongliang Jiang*, Michelle J. Cannon, Maria Banach, Anatoly N. Pinchuk, Giangthy N. Ton, Christie Scheuerell, Marc A. Longino, Jamey P. Weichert, Richard Tollefson, William R. Clarke, Qin C. Ji, Xiangyu Jiang, Quantification of CLR1401, a Novel AlkylphosphocholineAnticancer Agent, in Rat Plasma by Hydrophilic Interaction Liquid Chromatography-tandem Mass Spectrometric Detection, Journal of Chromatography B, 2010, 878(19): 1513-1518.
39.Hongliang Jiang*, Christopher Randlett, HeikoJunga, XiangyuJiang, Qin C. Ji*, Using Supported Liquid Extraction together with CellobiohydrolaseChiral Stationary Phases-based Liquid Chromatography with Tandem Mass Spectrometry for Enantioselective Determination of Acebutolol and its Active Metabolite Diacetolol in Spiked Human Plasma, Journal of Chromatography B, 2009, 877(3): 173-180.
40.Hongliang Jiang*, XiangyuJiang, Qin C. Ji*, Enantioselective Determination of Alprenolol in Human Plasma by Liquid Chromatography with Tandem Mass Spectrometry Using CellobiohydrolaseChiral Stationary Phases, Journal of Chromatography B, 2008, 872(1-2): 121-127.
41.Jie Ding, Christina M. Sorensen, NavdeepJaitly, HongliangJiang, Daniel J. Orton, Matthew E. Monroe, Ronald J. Moore, Richard D. Smith, Thomas O. Metz*, Application of the Accurate Mass and Time Tag Approach in Studies of the Human Blood Lipidome, Journal of Chromatography B, 2008, 871(2): 243-252.
42.Wei-jun Qian, David T. Kaleta, Brianne O. Petritis, HongliangJiang, Tao Liu, Xu Zhang, Heather M. Mottaz, Susan M. Varnum, David G. Camp, Lei Huang, XiangmingFang, Wei-weiZhang, Richard D. Smith*, Enhanced Detection of Low Abundance Human Plasma Proteins Using a Tandem IgY12-SuperMix ImmunoaffinitySeparation Strategy, Molecular & Cellular Proteomics, 2008, 7(10): 1963-1973.
43.Hongliang Jiang*, YingheLi, Mary Pelzer, Michelle J. Cannon, Christopher Randlett, HeikoJunga, XiangyuJiang, Qin C. Ji*, Determination of MolindoneEnantiomers in Human Plasma by High-performance Liquid Chromatography-tandem Mass Spectrometry Using Macrocyclic Antibiotic Chiral Stationary Phases, Journal of Chromatography A, 2008, 1192(2): 230-238.
44.Jie Ding, Christina M. Sorensen, QibinZhang, HongliangJiang, NavdeepJaitly, Eric A. Livesay, YufengShen, Richard D. Smith, Thomas O. Metz*. Capillary LC Coupled with High-Mass Measurement Accuracy Mass Spectrometry for Metabolic Profiling, Analytical Chemistry, 2007, 79(16): 6081-6093.
45.HongliangJiang, Barbara N. Timmermann, David R. Gang*, Characterization and Identification of Diarylheptanoids in Ginger (ZingiberofficinaleRosc.) Using High-performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2007, 21(4): 509-518.
46.Hongliang Jiang, Arpad Somogyi, Barbara N. Timmermann, David R. Gang*, Instrument Dependence of Electrospray ionization and tandem mass spectrometric fragmentation of the gingerols, Rapid Communications in Mass Spectrometry, 2006, 20(20): 3089-3100.
47.HongliangJiang, Barbara N. Timmermann, David R. Gang*, Use of Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry to Identify Diarylheptanoids in Turmeric (Curcuma longa L.) Rhizome, Journal of Chromatography A, 2006, 1111(1): 21-31.
48.Hongliang Jiang, Arpad Somogyi, Neil E. Jacobsen, Barbara N. Timmermann, David R. Gang*, Analysis of Curcuminoids by Positive and Negative Electrospray Ionization and Tandem Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2006, 20(6): 1001-1012.
49.Hongliang Jiang, ZhengzhiXie, Hyun Jo Koo, Steven P. McLaughlin, Barbara N. Timmermann, David R. Gang*, Metabolic Profiling and Phylogenetic Analysis of Medicinal ZingiberSpecies: Tools for Authentication of Ginger (ZingiberofficinaleRosc),Phytochemistry, 2006, 67(15): 1673-1685.
50.Hongliang Jiang, Aniko M. Solyom, Barbara N. Timmermann, David R. Gang*,Charaterization of Gingerol-related Compounds in Ginger Rhizome (ZingiberofficinaleRosc.) by High-performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2005, 19(20): 2957-2964.
51.廖梅，姜宏梁*.HPLC-MS同时测定药用紫草中13种紫草素和紫草呋喃类化合物的含量.中国药学杂志，2016，51（14），1212-1218.
52.屈文，程忠哲，李文溢，余启枝，易平，郑艳华，童瑶，刘嵌崎，程文华，李爽，杨光洁，许中怀，姜宏梁，张杨*.高效液相色谱-串联质谱法研究哌虫啶在大鼠体内的吸收、分布及排泄. 农药学学报，2015,17(6), 680-687.
53.姜宏梁，杨学东，张达，徐丽珍，杨世林，邹忠梅.中药北刘寄奴的化学成分研究.中国药学杂志，2003，38(2),97-99.
54.姜宏梁，徐丽珍，杨学东，张达，杨世林，邹忠梅.北刘寄奴中奎尼酸酯类化学成分研究.中国中药杂志，2002,27(12),923-926.
55.张达，姜宏梁，杨学东，徐丽珍，杨世林，邹忠梅.北刘寄奴中黄酮类化学成分的研究.中草药,2002,33(11),974-975.
五、联系方式：
Email:jianghongliang@hust.edu.cn；jianghongliang668@163.com
电话:027-66663909.
地址：湖北省武汉市航空路13号我校同济医学院新葡萄3522登录网页版2号楼，430030
